Airway smooth muscle in the pathophysiology and treatment of asthma

被引：127
作者：
Doeing, Diana C. [1 ]
Solway, Julian [1 ]
机构：
[1] Univ Chicago, Dept Med, Chicago, IL 60637 USA
来源：
JOURNAL OF APPLIED PHYSIOLOGY | 2013年 / 114卷 / 07期
基金：
美国国家卫生研究院;
关键词：
airflow obstruction; inflammation; airway remodeling; GROWTH-FACTOR-BETA; ADRENERGIC-RECEPTOR POLYMORPHISMS; MEDIATED CA2+ SENSITIZATION; MAST-CELL; RHO-KINASE; BRONCHIAL THERMOPLASTY; EOSINOPHILIC ASTHMA; TGF-BETA; IN-VITRO; BETA-2-ADRENERGIC RECEPTOR;
D O I：
10.1152/japplphysiol.00950.2012
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Airway smooth muscle in the pathophysiology and treatment of asthma. J Appl Physiol 114: 834-843, 2013. First published January 10, 2013; doi:10.1152/japplphysiol.00950.2012.-Airway smooth muscle (ASM) plays an integral part in the pathophysiology of asthma. It is responsible for acute bronchoconstriction, which is potentiated by constrictor hyperresponsiveness, impaired relaxation and length adaptation. ASM also contributes to airway remodeling and inflammation in asthma. In light of this, ASM is an important target in the treatment of asthma.
引用
收藏
页码：834 / 843
页数：10
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