Airway smooth muscle in the pathophysiology and treatment of asthma

被引：127
作者：
Doeing, Diana C. [1 ]
Solway, Julian [1 ]
机构：
[1] Univ Chicago, Dept Med, Chicago, IL 60637 USA
来源：
JOURNAL OF APPLIED PHYSIOLOGY | 2013年 / 114卷 / 07期
基金：
美国国家卫生研究院;
关键词：
airflow obstruction; inflammation; airway remodeling; GROWTH-FACTOR-BETA; ADRENERGIC-RECEPTOR POLYMORPHISMS; MEDIATED CA2+ SENSITIZATION; MAST-CELL; RHO-KINASE; BRONCHIAL THERMOPLASTY; EOSINOPHILIC ASTHMA; TGF-BETA; IN-VITRO; BETA-2-ADRENERGIC RECEPTOR;
D O I：
10.1152/japplphysiol.00950.2012
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Airway smooth muscle in the pathophysiology and treatment of asthma. J Appl Physiol 114: 834-843, 2013. First published January 10, 2013; doi:10.1152/japplphysiol.00950.2012.-Airway smooth muscle (ASM) plays an integral part in the pathophysiology of asthma. It is responsible for acute bronchoconstriction, which is potentiated by constrictor hyperresponsiveness, impaired relaxation and length adaptation. ASM also contributes to airway remodeling and inflammation in asthma. In light of this, ASM is an important target in the treatment of asthma.
引用
收藏
页码：834 / 843
页数：10
相关论文
共 151 条
[1]   Remodeling in asthma [J].
Al-Muhsen, Saleh ;
Johnson, Jill R. ;
Hamid, Qutayba .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 128 (03) :451-462
[2]   Mast cell numbers are increased in the smooth muscle of human sensitized isolated bronchi [J].
Ammit, AJ ;
Bekir, SS ;
Johnson, PRA ;
Hughes, JM ;
Armour, CL ;
Black, JL .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1997, 155 (03) :1123-1129
[3]   Airway smooth muscle dynamics:: a common pathway of airway obstruction in asthma [J].
An, S. S. ;
Bai, T. R. ;
Bates, J. H. T. ;
Black, J. L. ;
Brown, R. H. ;
Brusasco, V. ;
Chitano, P. ;
Deng, L. ;
Dowell, M. ;
Eidelman, D. H. ;
Fabry, B. ;
Fairbank, N. J. ;
Ford, L. E. ;
Fredberg, J. J. ;
Gerthoffer, W. T. ;
Gilbert, S. H. ;
Gosens, R. ;
Gunst, S. J. ;
Halayko, A. J. ;
Ingram, R. H. ;
Irvin, C. G. ;
James, A. L. ;
Janssen, L. J. ;
King, G. G. ;
Knight, D. A. ;
Lauzon, A. M. ;
Lakser, O. J. ;
Ludwig, M. S. ;
Lutchen, K. R. ;
Maksym, G. N. ;
Martin, J. G. ;
Mauad, T. ;
McParland, B. E. ;
Mijailovich, S. M. ;
Mitchell, H. W. ;
Mitchell, R. W. ;
Mitzner, W. ;
Murphy, T. M. ;
Pare, P. D. ;
Pellegrino, R. ;
Sanderson, M. J. ;
Schellenberg, R. R. ;
Seow, C. Y. ;
Silveira, P. S. P. ;
Smith, P. G. ;
Solway, J. ;
Stephens, N. L. ;
Sterk, P. J. ;
Stewart, A. G. ;
Tang, D. D. .
EUROPEAN RESPIRATORY JOURNAL, 2007, 29 (05) :834-860
[4]   How does exercise cause asthma attacks? [J].
Anderson, SD .
CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 6 (01) :37-42
[5]   Biochemical Basis of Asthma Therapy [J].
Barnes, Peter J. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (38) :32899-32905
[6]   Airway structural alterations selectively associated with severe asthma [J].
Benayoun, L ;
Druilhe, A ;
Dombret, MC ;
Aubier, M ;
Pretolani, M .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2003, 167 (10) :1360-1368
[7]   Mast cell myositis: a new feature of allergic asthma? [J].
Berger, P ;
Girodet, PO ;
Tunon-de-Lara, JM .
ALLERGY, 2005, 60 (10) :1238-1240
[8]   Tryptase-stimulated human airway smooth muscle cells induce cytokine synthesis and mast cell chemotaxis [J].
Berger, P ;
Girodet, PO ;
Begueret, H ;
Ousova, O ;
Perng, DW ;
Marthan, R ;
Walls, AF ;
de Lara, JMT .
FASEB JOURNAL, 2003, 17 (12) :2139-+
[9]   Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma [J].
Berry, Mike ;
Morgan, Angela ;
Shaw, Dominick E. ;
Parker, Deborah ;
Green, Ruth ;
Brightling, Christopher ;
Bradding, Peter ;
Wardlaw, Andrew J. ;
Pavord, Ian D. .
THORAX, 2007, 62 (12) :1043-1049
[10]   Chronic Activation in Shortened Airway Smooth Muscle A Synergistic Combination Underlying Airway Hyperresponsiveness? [J].
Bosse, Ynuk ;
Chin, Leslie Y. M. ;
Pare, Peter D. ;
Seow, Chun Y. .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2010, 42 (03) :341-348
12345678910