Solid phase synthesis of tetrahydropyrazine-2-ones by intramolecular Mitsunobu reactions

被引：26

作者：

Kung, PP ^{[1
]}

Swayze, E ^{[1
]}

机构：

[1] ISIS Pharmaceut, Ibis Therapeut, Carlsbad, CA 92008 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 31期

关键词：

D O I：

10.1016/S0040-4039(99)01102-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel route for the synthesis of tetrahydropyrazine-2-ones on solid support through intramolecular Mitsunobu reactions is reported. The syntheses employ reductive amination of commercially available amino alcohols to attach them to ArgoGel-MB-CHO resin. Amino acids are then coupled to the derivatized solid support for construction of the ring systems and a Mitsunobu reaction between the activated amino acids and amino alcohols forms the derivatized tetrahydropyrazine-2-one rings. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：5651 / 5654

页数：4

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