Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection

被引：333

作者：

Fernandez-Ruiz, Daniel ^{[1
]}

Ng, Wei Yi ^{[1
,2
]}

Holz, Lauren E. ^{[1
,4
]}

Ma, Joel Z. ^{[1
]}

Zaid, Ali ^{[1
,4
]}

Wong, Yik Chun ^{[6
,7
,8
]}

Lau, Lei Shong ^{[1
]}

Mollard, Vanessa ^{[3
]}

Cozijnsen, Anton ^{[3
]}

Collins, Nicholas ^{[1
]}

Li, Jessica ^{[1
,2
]}

Davey, Gayle M. ^{[1
,4
]}

Kato, Yu ^{[1
]}

Devi, Sapna ^{[1
,4
]}

Skandari, Roghieh ^{[5
]}

Pauley, Michael ^{[5
]}

Manton, Jonathan H. ^{[5
]}

Godfrey, Dale I. ^{[1
,4
]}

Braun, Asolina ^{[1
]}

Tay, Szun Szun ^{[6
,7
,8
]}

Tan, Peck Szee ^{[2
,10
,11
]}

Bowen, David G. ^{[6
,7
,8
]}

Koch-Nolte, Friedrich ^{[9
]}

Rissiek, Bjoern ^{[9
]}

Carbone, Francis R. ^{[1
]}

Crabb, Brendan S. ^{[2
]}

Lahoud, Mireille ^{[2
,10
,11
]}

Cockburn, Ian A. ^{[12
]}

Mueller, Scott N. ^{[1
,4
]}

Bertolino, Patrick ^{[6
,7
,8
]}

McFadden, Geoffrey I. ^{[3
]}

Caminschi, Irina ^{[2
,10
,11
]}

Heath, William R. ^{[1
,4
]}

机构：

[1] Univ Melbourne, Peter Doherty Inst, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

[2] Macfarlane Burnet Inst Med Res & Publ Hlth, Melbourne, Vic 3004, Australia

[3] Univ Melbourne, Sch BioSci, Parkville, Vic 3010, Australia

[4] Univ Melbourne, ARC Ctr Excellence Adv Mol Imaging, Parkville, Vic 3010, Australia

[5] Univ Melbourne, Dept Elect & Elect Engn, Parkville, Vic 3010, Australia

[6] Univ Sydney, Liver Immunol Program, Centenary Inst, Locked Bag 6, Sydney, NSW 2042, Australia

[7] Univ Sydney, AW Morrow Gastroenterol & Liver Ctr, Locked Bag 6, Sydney, NSW 2042, Australia

[8] Royal Prince Alfred Hosp, Locked Bag 6, Sydney, NSW 2042, Australia

[9] Univ Med Ctr Hamburg Eppendorf, Inst Immunol, Martinistr 52, D-20246 Hamburg, Germany

[10] Monash Univ, Infect & Immun Program, Monash Biomed Discovery Inst, Clayton, Vic 3168, Australia

[11] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3168, Australia

[12] Australian Natl Univ, John Curtin Sch Med Res, Dept Immunol & Infect Dis, Canberra, ACT 2601, Australia

来源：

IMMUNITY | 2016年 / 45卷 / 04期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

DENDRITIC CELLS; RM CELLS; TISSUE; PROTECTION; IMMUNITY; IMMUNIZATION; STRATEGY; ANTIGEN; HERPES;

D O I：

10.1016/j.immuni.2016.08.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In recent years, various intervention strategies have reduced malaria morbidity and mortality, but further improvements probably depend upon development of a broadly protective vaccine. To better understand immune requirement for protection, we examined liver-stage immunity after vaccination with irradiated sporozoites, an effective though logistically difficult vaccine. We identified a population of memory CD8(+) T cells that expressed the gene signature of tissueresident memory T (Trm) cells and remained permanently within the liver, where they patrolled the sinusoids. Exploring the requirements for liver Trm cell induction, we showed that by combining dendritic cell-targeted priming with liver inflammation and antigen recognition on hepatocytes, high frequencies of Trm cells could be induced and these cells were essential for protection against malaria sporozoite challenge. Our study highlights the immune potential of liver Trmcells and provides approaches for their selective transfer, expansion, ordepletion, whichmay be harnessed to control liver infections or autoimmunity.

引用

页码：889 / 902

页数：14

共 42 条

[1] Efficacy and Safety of the RTS,S/AS01 Malaria Vaccine during 18 Months after Vaccination: A Phase 3 Randomized, Controlled Trial in Children and Young Infants at 11 African Sites [J].

Agnandji, Selidji Todagbe ;

Lell, Bertrand ;

Fernandes, Jose Francisco ;

Abossolo, Beatrice Peggy ;

Kabwende, Anita Lumeka ;

Adegnika, Ayola Akim ;

Mordmueller, Benjamin ;

Issifou, Saadou ;

Kremsner, Peter Gottfried ;

Loembe, Marguerite Massinga ;

Sacarlal, Jahit ;

Aide, Pedro ;

Madrid, Lola ;

Lanaspa, Miguel ;

Mandjate, Sofia ;

Aponte, John J. ;

Bulo, Helder ;

Nhama, Abel ;

Macete, Eusebio ;

Alonso, Pedro ;

Abdulla, Salim ;

Salim, Nahya ;

Mtoro, Ali Takadir ;

Mutani, Paul ;

Tanner, Marcel ;

Mavere, Caroline ;

Mwangoka, Grace ;

Lweno, Omar ;

Juma, Omar Ali ;

Shekalaghe, Seif ;

Tinto, Halidou ;

D'Alessandro, Umberto ;

Sorgho, Hermann ;

Valea, Innocent ;

Ouedraogo, Jean Bosco ;

Lompo, Palpouguini ;

Diallo, Salou ;

Traore, Ousmane ;

Bassole, Armand ;

Dao, Edgard ;

Hamel, Mary J. ;

Kariuki, Simon ;

Oneko, Martina ;

Odero, Chris ;

Otieno, Kephas ;

Awino, Norbert ;

Muturi-Kioi, Vincent ;

Omoto, Jackton ;

Laserson, Kayla F. ;

Slutsker, Laurence .

PLOS MEDICINE, 2014, 11 (07)

[2]

Benedict MQ, 1997, MOL BIOL INSECT DIS, P2, DOI DOI 10.1126/science.1241800

[3] Protracted protection to Plasmodium berghei malaria is linked to functionally and phenotypically heterogeneous liver memory CD8+ T cells [J].

Berenzon, D ;

Schwenk, RJ ;

Letellier, L ;

Guebre-Xabier, M ;

Williams, J ;

Krzych, U .

JOURNAL OF IMMUNOLOGY, 2003, 171 (04) :2024-2034

[4] Proinflammatory microenvironments within the intestine regulate the differentiation of tissue-resident CD8+ T cells responding to infection [J].

Bergsbaken, Tessa ;

Bevan, Michael J. .

NATURE IMMUNOLOGY, 2015, 16 (04) :406-414

[5] Whole parasite vaccination approaches for prevention of malaria infection [J].

Butler, Noah S. ;

Vaughan, Ashley M. ;

Harty, John T. ;

Kappe, Stefan H. I. .

TRENDS IN IMMUNOLOGY, 2012, 33 (05) :247-254

[6] In vivo CD8+T Cell Dynamics in the Liver of Plasmodium yoelii Immunized and Infected Mice [J].

Cabrera, Mynthia ;

Pewe, Lecia L. ;

Harty, John T. ;

Frevert, Ute .

PLOS ONE, 2013, 8 (08)

[7] Prolonged Antigen Presentation Is Required for Optimal CD8+T Cell Responses against Malaria Liver Stage Parasites [J].

Cockburn, Ian A. ;

Chen, Yun-Chi ;

Overstreet, Michael G. ;

Lees, Jason R. ;

van Rooijen, Nico ;

Farber, Donna L. ;

Zavala, Fidel .

PLOS PATHOGENS, 2010, 6 (05) :1-13

[8] Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8+ T Cell Immunity [J].

Epstein, J. E. ;

Tewari, K. ;

Lyke, K. E. ;

Sim, B. K. L. ;

Billingsley, P. F. ;

Laurens, M. B. ;

Gunasekera, A. ;

Chakravarty, S. ;

James, E. R. ;

Sedegah, M. ;

Richman, A. ;

Velmurugan, S. ;

Reyes, S. ;

Li, M. ;

Tucker, K. ;

Ahumada, A. ;

Ruben, A. J. ;

Li, T. ;

Stafford, R. ;

Eappen, A. G. ;

Tamminga, C. ;

Bennett, J. W. ;

Ockenhouse, C. F. ;

Murphy, J. R. ;

Komisar, J. ;

Thomas, N. ;

Loyevsky, M. ;

Birkett, A. ;

Plowe, C. V. ;

Loucq, C. ;

Edelman, R. ;

Richie, T. L. ;

Seder, R. A. ;

Hoffman, S. L. .

SCIENCE, 2011, 334 (6055) :475-480

[9] Preferential migration of effector CD8+ T cells into the interstitium of the normal lung [J].

Galkina, E ;

Thatte, J ;

Dabak, V ;

Williams, MB ;

Ley, K ;

Braciale, TJ .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (12) :3473-3483

[10] Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids [J].

Geissmann, F ;

Cameron, TO ;

Sidobre, S ;

Manlongat, N ;

Kronenberg, M ;

Briskin, MJ ;

Dustin, ML ;

Littman, DR .

PLOS BIOLOGY, 2005, 3 (04) :650-661

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