Anti-Leukemia Activity of Au/CuO/ZnO Nanoparticles Synthesized usedVerbena officinalisExtract

被引：13
作者：
Dobrucka, Renata [1 ]
Romaniuk-Drapala, Aleksandra [2 ]
Kaczmarek, Mariusz [3 ,4 ]
机构：
[1] Poznan Univ Econ & Business, Inst Qual Sci, Dept Nonfood Prod Qual & Packaging Dev, Al Niepodleglosci 10, PL-61875 Poznan, Poland
[2] Poznan Univ Med Sci, Dept Clin Chem & Mol Diagnost, 49 Przybyszewskiego St, PL-60355 Poznan, Poland
[3] Poznan Univ Med Sci, Dept Canc Immunol, Chair Med Biotechnol, Garbary 15 Str, PL-61866 Poznan, Poland
[4] Greater Poland Canc Ctr, Dept Canc Diagnost & Immunol, Gene Therapy Lab, Garbary 15 Str, PL-61866 Poznan, Poland
来源：
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS | 2021年 / 31卷 / 01期
关键词：
Biosynthesis; Verbena officinalis; Leukemia; ZINC-OXIDE NANOPARTICLES; ZNO NANOPARTICLES; ANTICANCER ACTIVITY; GREEN SYNTHESIS; LEAF EXTRACT; ANTIBACTERIAL; BIOSYNTHESIS; DELIVERY; CELLS; GOLD;
D O I：
10.1007/s10904-020-01690-8
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
As biological synthesis has become an alternative to chemical and physical methods for synthesizing nanoparticles, this work describes the synthesis of Au/CuO/ZnO nanoparticles usingVerbena officinalisextract. The synthesized Au/CuO/ZnO nanoparticles were characterized using Ultraviolet-Visible, Fourier Transform-Infrared, Transmission Electron Microscopy and Atomic Force Microscopy. The influence of Au/CuO/ZnO nanoparticles on cell viability was evaluated in vitro, using the established cell line - Jurkat (ATCC (R) TIB-152 (TM)). The Annexin V binding test confirmed the previous results of the MTT assay, which indicate that the studied complex of Au/CuO/ZnO nanoparticles has a strong cytotoxic effect on the Jurkat cell line. The type of death and the effectiveness of cell elimination depended both on the concentration of the complex and the duration of culture.
引用
收藏
页码：191 / 202
页数：12
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