Proteasomes and other self-compartmentalizing proteases in prokaryotes

被引：119

作者：

De Mot, R ^{[1
]}

Nagy, I

Walz, J

Baumeister, W

机构：

[1] Katholieke Univ Leuven, Genet Lab, B-3001 Heverlee, Belgium

[2] Max Planck Inst Biochem, Abt Mol Strukturbiol, D-82152 Martinsried, Germany

来源：

TRENDS IN MICROBIOLOGY | 1999年 / 7卷 / 02期

关键词：

D O I：

10.1016/S0966-842X(98)01432-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The proteasome represents the major nonlysosomal proteolytic system in eukaryotes. It confines proteolytic activity to an inner compartment that is accessible to unfolded proteins only. The strategy of controlling intracellular breakdown of proteins by self-compartmentalization is also used by different types of prokaryotic energy-dependent proteases. Genomic sequencing data reveal that various combinations of these energy-dependent proteases occur in prokaryotic cells from different lineages.

引用

页码：88 / 92

页数：5

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