Deep inspiration breath-hold (DIBH) radiotherapy in left-sided breast cancer

被引：1

作者：

Hepp, Rodrigo ^{[1
]}

Ammerpohl, Mark ^{[1
]}

Morgenstern, Christina ^{[1
]}

Nielinger, Lisa ^{[1
,2
]}

Erichsen, Patricia ^{[1
]}

Abdallah, Abdallah ^{[3
]}

Galalae, Razvan ^{[1
,4
]}

机构：

[1] Evangel Kliniken Gelsenkirchen, Klin Strahlentherapie & Radioonkol, D-45879 Gelsenkirchen, Germany

[2] Hsch Hamm Lippstadt, Lippstadt, Germany

[3] Evangel Kliniken Gelsenkirchen, Klin Senol, D-45879 Gelsenkirchen, Germany

[4] Univ Kiel, Fac Med, Kiel, Germany

来源：

STRAHLENTHERAPIE UND ONKOLOGIE | 2015年 / 191卷 / 09期

关键词：

Radiotherapy; Breast cancer; Cardiac dose; Deep inspiration breath-hold; Surface scanner; MODULATED RADIATION-THERAPY; HEART-DISEASE; MONTE-CARLO; RISK; WOMEN; MORTALITY; IRRADIATION; GUIDELINES; REDUCTION;

D O I：

10.1007/s00066-015-0838-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Adjuvant radiotherapy after breast-conserving surgery (BCS) for breast cancer (BC) is a well-established indication. The risk of ischaemic heart disease after radiotherapy for BC increases linearly with the heart mean dose with no apparent threshold. Radiotherapy to the left breast in deep inspiration breath-hold (DIBH) reduces the dose to the heart. A new linac system with an integrated surface scanner (SS) for DIBH treatments was recently installed in our department. We tested it for potential benefits, safety, patients' acceptance/compliance and associated additional workload. Materials and methods Twenty consecutive patients following BCS for breast carcinoma of the left side were enrolled in our institutional DIBH protocol. We compared dose to the heart and ipsilateral lung (IL) between plans in DIBH and free breathing (FB) using standard defined parameters: mean dose, maximal dose to a volume of 2 cm(3) (D-2 cm(3)), volume receiving >= 5 Gy (V-5), 10 Gy (V-10), 15 Gy (V-15) and 20 Gy (V-20). Comparison of median calculated dose values was performed using a two-tailed Wilcoxon signed rank test. Results DIBH was associated with a statistically significant reduction (p < 0.001) in all studied parameters for the heart and the IL. In 16 of 20 patients the heart D-2 cm(3) was less than 42 Gy in DIBH. In FB the heart D-2 cm(3) was >= 42 Gy in 17 of 20 patients. The median daily treatment time was 9 min. Conclusion Radiotherapy of the left breast in DIBH using a SS could easily be incorporated into daily routine and is associated with significant dose reduction to the heart and IL.

引用

页码：710 / 716

页数：7

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