Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study

被引：26

作者：

Ferrari, P. ^{[1
]}

McKay, J. D. ^{[1
]}

Jenab, M. ^{[1
]}

Brennan, P. ^{[1
]}

Canzian, F. ^{[2
]}

Vogel, U. ^{[3
]}

Tjonneland, A. ^{[4
]}

Overvad, K. ^{[5
]}

Tolstrup, J. S. ^{[6
]}

Boutron-Ruault, M-C ^{[7
]}

Clavel-Chapelon, F. ^{[7
]}

Morois, S. ^{[7
]}

Kaaks, R. ^{[2
]}

Boeing, H. ^{[8
]}

Bergmann, M. ^{[8
]}

Trichopoulou, A. ^{[9
,10
]}

Katsoulis, M. ^{[9
,10
]}

Trichopoulos, D. ^{[11
]}

Krogh, V. ^{[12
]}

Panico, S. ^{[13
]}

Sacerdote, C. ^{[14
]}

Palli, D. ^{[15
]}

Tumino, R. ^{[16
]}

Peeters, P. H. ^{[17
]}

van Gils, C. H. ^{[17
]}

Bueno-de-Mesquita, B. ^{[18
,19
]}

Vrieling, A. ^{[2
,19
]}

Lund, E. ^{[20
]}

Hjartaker, A. ^{[21
]}

Agudo, A. ^{[22
]}

Suarez, L. R. ^{[23
]}

Arriola, L. ^{[24
]}

Chirlaque, M-D ^{[25
,26
]}

Ardanaz, E. ^{[27
,28
]}

Sanchez, M-J ^{[29
,30
]}

Manjer, J. ^{[31
]}

Lindkvist, B. ^{[32
]}

Hallmans, G. ^{[33
]}

Palmqvist, R. ^{[34
]}

Allen, N. ^{[35
]}

Key, T. ^{[35
]}

Khaw, K-T ^{[36
]}

Slimani, N. ^{[1
]}

Rinaldi, S. ^{[1
]}

Romieu, I. ^{[1
]}

Boffetta, P. ^{[37
,38
,39
]}

Romaguera, D. ^{[40
]}

Norat, T. ^{[40
]}

Riboli, E. ^{[40
]}

机构：

[1] Int Agcy Res Canc, WHO, F-69372 Lyon 08, France

[2] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany

[3] Tech Univ Denmark, Natl Food Inst, Dept Toxicol & Risk Assessment, Soborg, Denmark

[4] Danish Canc Soc, Inst Canc Epidemiol, Dept Diet Canc & Hlth, Copenhagen, Denmark

[5] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[6] Univ So Denmark, Natl Inst Publ Hlth, Copenhagen, Denmark

[7] Inst Gustave Roussy, INSERM, U1018, Ctr Res Epidemiol & Populat Hlth, F-94805 Villejuif, France

[8] German Inst Human Nutr Potsdam Rehbrucke, Nuthetal, Germany

[9] Hellen Hlth Fdn, Athens, Greece

[10] Univ Athens, Sch Med, WHO Collaborating Ctr Food & Nutr Policies, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

[11] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[12] Fdn IRCSS Ist Nazl Tumori, Nutr Epidemiol Unit, Dept Prevent & Predict Med, Milan, Italy

[13] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[14] CPO Piemonte, Ctr Canc Epidemiol & Prevent, Turin, Italy

[15] ISPO, Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, Florence, Italy

[16] Azienda Osped Civile MP Arezzo, Canc Registry, Ragusa, Italy

[17] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[18] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[19] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[20] Univ Tromso, Inst Community Med, Tromso, Norway

[21] Inst Population Based Canc Res, Canc Registry Norway, Oslo, Norway

[22] Catalan Inst Oncol, Unit Nutr Environm & Canc, Barcelona, Spain

[23] Hlth & Hlth Care Serv Council, Publ Hlth Directorate, Oviedo, Spain

[24] CIBERESP, Basque Govt, Publ Hlth Dept Gipuzkoa, San Sebastian, Spain

[25] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[26] CIBERESP, Murcia, Spain

[27] Publ Hlth Inst Navarra, Pamplona, Spain

[28] CIBERESP, Pamplona, Spain

[29] Andalusian Sch Publ Hlth, Granada, Spain

[30] CIBERESP, Granada, Spain

[31] Malmo Univ Hosp, Dept Surg, Malmo, Sweden

[32] Sahlgrens Univ Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, Gothenburg, Sweden

[33] Dept Publ Hlth & Clin Med, Umea, Sweden

[34] Umea Univ, Dept Med Biosci, Umea, Sweden

[35] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[36] Univ Cambridge, Clin Gerontol Unit, Cambridge, England

[37] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY USA

[38] Mt Sinai Sch Med, Inst Translat Epidemiol, New York, NY USA

[39] Int Prevent Res Inst, Lyon, France

[40] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

来源：

EUROPEAN JOURNAL OF CLINICAL NUTRITION | 2012年 / 66卷 / 12期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

acetaldehyde; aldehyde dehydrogenase; polymorphism; alcohol intake; colorectal cancer; DOSE-RESPONSE METAANALYSIS; UPPER AERODIGESTIVE TRACT; ACETALDEHYDE PRODUCTION; POOLED ANALYSIS; COLONIC FLORA; NECK-CANCER; METABOLISM; ETHANOL; CONSUMPTION; ADH;

D O I：

10.1038/ejcn.2012.173

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

BACKGROUND/OBJECTIVES: Heavy alcohol drinking is a risk factor of colorectal cancer (CRC), but little is known on the effect of polymorphisms in the alcohol-metabolizing enzymes, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) on the alcohol-related risk of CRC in Caucasian populations. SUBJECTS/METHODS: A nested case-control study (1269 cases matched to 2107controls by sex, age, study centre and date of blood collection) was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the impact of rs1229984 (ADH1B), rs1573496 (ADH7) and rs441 (ALDH2) polymorphisms on CRC risk. Using the wild-type variant of each polymorphism as reference category, CRC risk estimates were calculated using conditional logistic regression, with adjustment for matching factors. RESULTS: Individuals carrying one copy of the rs1229984(A) (ADH1B) allele (fast metabolizers) showed an average daily alcohol intake of 4.3 g per day lower than subjects with two copies of the rs1229984(G) allele (slow metabolizers) (P-diff<0.01). None of the polymorphisms was associated with risk of CRC or cancers of the colon or rectum. Heavy alcohol intake was more strongly associated with CRC risk among carriers of the rs1573496(C) allele, with odds ratio equal to 2.13 (95% confidence interval: 1.26-3.59) compared with wild-type subjects with low alcohol consumption P-((interaction)=0.07). CONCLUSIONS: The rs1229984(A) (ADH1B) allele was associated with a reduction in alcohol consumption. The rs1229984 (ADH1B), rs1573496 (ADH7) and rs441 (ALDH2) polymorphisms were not associated with CRC risk overall in Western-European populations. However, the relationship between alcohol and CRC risk might be modulated by the rs1573496 (ADH7) polymorphism. European Journal of Clinical Nutrition (2012) 66, 1303-1308; doi: 10.1038/ejcn.2012.173; published online 14 November 2012

引用

页码：1303 / 1308

页数：6

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