Catalytic Enantioselective Allylic Amination of Unactivated Terminal Olefins via an Ene Reaction/[2,3]-Rearrangement

被引：75

作者：

Bao, Hongli ^{[1
]}

Tambar, Uttam K. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Biochem, Div Chem, Dallas, TX 75390 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 45期

基金：

美国国家卫生研究院;

关键词：

C-H AMINATION; BONDS; AMIDATION; INSIGHTS; ALKENES; REARRANGEMENT; DIAMINATION; ACETYLENES; ACTIVATION; CARBON;

D O I：

10.1021/ja307851b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The enantioselective allylic am nation. of unactivated terminal olefins represents a direct and attractive strategy for the synthesis of enantioenriched amines. We have developed the first use of a nitrogen. containing reagent and a chiral palladium catalyst to convert unfunctionalized olefins into enantioenriched allylic amines via an ene reaction/[2,3]-rearrangement.

引用

页码：18495 / 18498

页数：4

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