Aging and Rejuvenation of Neural Stem Cells and Their Niches

被引：173
作者：
Negredo, Paloma Navarro [1 ]
Yeo, Robin W. [1 ]
Brunet, Anne [1 ,2 ]
机构：
[1] Stanford Univ, Dept Genet, Stanford, CA 94305 USA
[2] Glenn Labs Biol Aging, Stanford, CA 94305 USA
来源：
CELL STEM CELL | 2020年 / 27卷 / 02期
关键词：
ADULT HIPPOCAMPAL NEUROGENESIS; FATTY-ACID OXIDATION; CENTRAL-NERVOUS-SYSTEM; AGE-RELATED-CHANGES; SUBVENTRICULAR ZONE; DENTATE GYRUS; SELF-RENEWAL; COGNITIVE FUNCTION; EPENDYMAL CELLS; STEM/PROGENITOR CELLS;
D O I：
10.1016/j.stem.2020.07.002
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Aging has a profound and devastating effect on the brain. Old age is accompanied by declining cognitive function and enhanced risk of brain diseases, including cancer and neurodegenerative disorders. A key question is whether cells with regenerative potential contribute to brain health and even brain "rejuvenation.'' This review discusses mechanisms that regulate neural stem cells (NSCs) during aging, focusing on the effect of metabolism, genetic regulation, and the surrounding niche. We also explore emerging rejuvenating strategies for old NSCs. Finally, we consider how new technologies may help harness NSCs' potential to restore healthy brain function during physiological and pathological aging.
引用
收藏
页码：202 / 223
页数：22
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