Catechin protects against oxidative stress and inflammatory-mediated cardiotoxicity in adriamycin-treated rats

被引：109

作者：

Abd El-Aziz, Tarek A. ^{[2
]}

Mohamed, Randa H. ^{[1
]}

Pasha, Heba F. ^{[1
]}

Abdel-Aziz, Hisham R. ^{[3
]}

机构：

[1] Zagazig Univ, Fac Med, Dept Med Biochem, Zagazig, Egypt

[2] Zagazig Univ, Dept Cardiol, Fac Med, Zagazig, Egypt

[3] Zagazig Univ, Fac Med, Dept Pathol, Zagazig, Egypt

来源：

CLINICAL AND EXPERIMENTAL MEDICINE | 2012年 / 12卷 / 04期

关键词：

Adriamycin; Catechin; Oxidative stress; Inflammation; NITRIC-OXIDE SYNTHASE; INDUCED CARDIOMYOPATHY; VITAMIN-E; DOXORUBICIN; TEA; EXPRESSION;

D O I：

10.1007/s10238-011-0165-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Catechin has anti-inflammatory and antioxidative effects. Cardiotoxicity, which results from intense cardiac oxidative stress and inflammation, is the main limiting factor of the adriamycin use in the treatment of malignant tumors. Thus, the present study aimed to assess the antioxidant and anti-inflammatory effects of catechin on adriamycin-induced cardiotoxicity in rats. Forty-five rats were allocated to three groups: control group, adriamycin group and adriamycin + catechin group. We performed the following measurements: lipid peroxidation (MDA), catalase (CAT), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities as well as, the expression of inflammatory cytokines genes namely nuclear factor kappa-B, tumor necrosis factor and inducible nitric oxide synthase. Catechin administration significantly decreased MDA level and significantly increased CAT, GSH-Px and SOD activities. Also, catechin significantly decreased the expression levels of inflammatory cytokines. Catechin provided cardioprotection on adriamycin-induced cardiotoxicity through their antioxidant and anti-inflammatory properties.

引用

页码：233 / 240

页数：8

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