Endophytes and associated marine derived fungi-ecological and chemical perspectives

被引:105
作者
Debbab, Abdessamad [1 ]
Aly, Amal H. [1 ]
Proksch, Peter [1 ]
机构
[1] Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, D-40225 Dusseldorf, Germany
关键词
Fungi; Endophytes; Associated marine fungi; Bioactive metabolites; Natural products; Biosynthetic pathways; PLANT-MICROBE INTERACTIONS; PIRIFORMOSPORA-INDICA; BIOACTIVE METABOLITES; NATURAL-PRODUCT; A-D; ASPERGILLUS-NIDULANS; SECONDARY METABOLITES; STRESS TOLERANCE; HOST; ANTIFUNGAL;
D O I
10.1007/s13225-012-0191-8
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The potential of endophytes and algal or invertebrate associated marine derived fungi as promising sources of structurally unprecedented bioactive natural products is undeniable and continues to attract broad attention. This review highlights new bioactive fungal metabolites reported in 2011 until April 2012, as well as known compounds for which novel biological activities have been disclosed. All compounds are grouped according to their reported biological activities which include cytotoxic, anti-infective, as well as radical scavenging, enzyme inhibition, anti-fouling and anti-parasitic activities. Overall, 178 fungal metabolites, including 138 new natural products are presented. Furthermore, new insights into fungal-host interaction, chemical communication, and chemo-ecological roles of fungal metabolites, as well as new strategies for bioprospecting are presented.
引用
收藏
页码:45 / 83
页数:39
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