MicroRNA-204-5p Inhibits Ovarian Cancer Cell Proliferation by Down-Regulating USP47

被引：26
作者：
Hu, Liangliang [1 ]
Kolibaba, Helena [2 ]
Zhang, Siyou [3 ]
Cao, Minhua [4 ]
Niu, Huihui [5 ]
Mei, Haoyan [5 ]
Hao, Yaming [6 ]
Xu, Yang [7 ]
Yin, Qinan [8 ]
机构：
[1] Hubei Polytech Inst, Med Fac, Xiaogan, Hubei, Peoples R China
[2] St Claraspital Hosp, CH-4058 Basel, Switzerland
[3] China Meitan Gen Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China
[4] Suzhou Municipal Hosp, Dept Obstet & Gynecol, Suzhou, Jiangsu, Peoples R China
[5] Jingmen 1 Peoples Hosp, Dept Obstet & Gynecol, Jingmen, Hubei, Peoples R China
[6] Wuhan 5 Hosp, Wuhan, Hubei, Peoples R China
[7] China Japan Friendship Hosp, Dept Obstet & Gynaecol, Beijing, Peoples R China
[8] NIH, Ctr Clin, Bethesda, MD 20892 USA
来源：
CELL TRANSPLANTATION | 2019年 / 28卷 / 1_SUPPL期
关键词：
miR-204-5p; USP47; ovarian cancer; cell proliferation; MIR-204-5P;
D O I：
10.1177/0963689719877372
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Ovarian cancer (OC) is the most lethal gynecologic cancer, and the incidence of OC has risen steadily worldwide. Numerous microRNAs (miRNAs) have been found to be involved in the progression of OC. miR-204-5p is down-regulated and functions as a tumor suppressor in various types of human malignant tumors. However, the biological roles and molecular mechanisms of miR-204-5p in OC still remain unclear. In this study, the aberrant down-regulation of miR-204-5p was detected in OC tissues. We also observed that miR-204-5p overexpression represses OC cell proliferation. Ubiquitin-specific peptidase 47 (USP47) is verified as the functional target of miR-204-5p, through which it plays an important biological role in OC. Our results uncover new functions and mechanisms for miR-204-5p in the progression of OC, and provide a potential therapeutic target for the treatment of OC.
引用
收藏
页码：51S / 58S
页数：8
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