Early tissue reaction in the tension zone of PDL during orthodontic tooth movement

被引:24
|
作者
Tsuge, A. [1 ]
Noda, K. [1 ]
Nakamura, Y. [1 ]
机构
[1] Tsurumi Univ, Sch Dent Med, Dept Orthodont, Yokohama, Kanagawa, Japan
基金
日本学术振兴会;
关键词
Interleukin-1; beta; Pentraxin; 3; Basic fibroblast growth factor; Inflammation; Laser capture microdissection; FIBROBLAST-GROWTH-FACTOR; RAT PERIODONTAL-LIGAMENT; OSTEOBLAST DIFFERENTIATION; INFLAMMATION; CELLS; INTERLEUKIN-1; INCIDENT; DISEASE; PROTEIN; PTX3;
D O I
10.1016/j.archoralbio.2016.01.007
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Objective: The aim of the study was to examine the early tissue reaction in the tension zone of periodontal ligament (PDL) during orthodontic tooth movement. Design: Upper first molars of rats were moved buccally with fixed appliances. The PDL in the tension zone was examined histologically, immunohistochemically and at a molecular level after 24 h, 3 days and 7 days. Results: After 24 h of orthodontic force loading, the periodontal space appeared considerably expanded. The periodontal fibers were stretched between the bone and the root. Three days after loading, the expanded periodontal space had slightly narrowed, the periodontal fiber arrangement was relaxed, and the blood vessels did not appear elongated. A considerable layer of osteoid was formed on the bone surface. The total cross-sectional areas of the PDL in experimental groups were significantly larger than control group. The total cross-sectional areas of the blood vessels were not significantly different among the groups. Significantly high expressions of IL-1 beta and PTX3 were characteristically observed not only in the endothelial cells and cells around the blood vessel, but also in fibroblasts throughout the PDL of the tension zone 24 h after orthodontic force loading. Three and 7 days after loading, these showed tendencies to return to control levels. Conclusions: The present results suggest that the early reaction in the tension zone of the PDL during tooth movement consists of two phases: first, inflammation and second, rapid recovery and renovation of the PDL with bone formation. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:17 / 25
页数:9
相关论文
共 50 条
  • [31] Osteocyte death during orthodontic tooth movement in mice
    Moin, Sogole
    Kalajzic, Zana
    Utreja, Achint
    Nihara, Jun
    Wadhwa, Sunil
    Uribe, Flavio
    Nanda, Ravindra
    ANGLE ORTHODONTIST, 2014, 84 (06) : 1086 - 1092
  • [32] Dynamic changes in transcriptome during orthodontic tooth movement
    Liu, Jia
    Chen, Po-Jung
    Mehta, Shivam
    Dutra, Eliane H.
    Yadav, Sumit
    ORTHODONTICS & CRANIOFACIAL RESEARCH, 2023, 26 : 73 - 81
  • [33] A model for evaluating friction during orthodontic tooth movement
    Loftus, BP
    Årtun, J
    EUROPEAN JOURNAL OF ORTHODONTICS, 2001, 23 (03) : 253 - 261
  • [34] Cystatins and cathepsin B during orthodontic tooth movement
    Rhee, Seung-Hoon
    Kang, Junghee
    Nahm, Dong-Seok
    AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS, 2009, 135 (01) : 99 - 105
  • [35] Computational simulation of the tooth movement during the orthodontic treatment
    Soncini, M
    Pietrabissa, R
    COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING - 3, 2001, : 565 - 570
  • [36] HISTOLOGIC STUDY OF PULPAL REACTION TO ORTHODONTIC TOOTH MOVEMENT IN DOGS
    ANSTENDIG, HS
    KRONMAN, JH
    ANGLE ORTHODONTIST, 1972, 42 (01) : 50 - +
  • [37] Expression of genes for gelatinases and tissue inhibitors of metalloproteinases in periodontal tissues during orthodontic tooth movement
    Takahashi, Ichiro
    Onodera, Kazuyuki
    Nishimura, Makoto
    Mitnai, Hidetoshi
    Sasano, Yasuyuki
    Mitani, Hideo
    JOURNAL OF MOLECULAR HISTOLOGY, 2006, 37 (8-9) : 333 - 342
  • [38] Matrix metalloproteinases and tissue inhibitors of metalloproteinases in gingival crevicular fluid during orthodontic tooth movement
    Bildt, M. M.
    Bloemen, M.
    Kuijpers-Jagtman, A. M.
    Von den Hoff, J. W.
    EUROPEAN JOURNAL OF ORTHODONTICS, 2009, 31 (05) : 529 - 535
  • [39] Expression of genes for gelatinases and tissue inhibitors of metalloproteinases in periodontal tissues during orthodontic tooth movement
    Ichiro Takahashi
    Kazuyuki Onodera
    Makoto Nishimura
    Hidetoshi Mitnai
    Yasuyuki Sasano
    Hideo Mitani
    Journal of Molecular Histology, 2006, 37 : 333 - 342
  • [40] Cbfa1 gene expression in periodontal tissue during orthodontic tooth movement.
    Yamashita, K
    Pereira, JN
    Wang, Y
    Takano-Yamamoto, T
    JOURNAL OF DENTAL RESEARCH, 2000, 79 : 470 - 470