Differentiation of human adipose-derived adult stem cells into neuronal tissue: Does it work?

被引：71
作者：
Franco Lambert, Ana Paula [1 ]
Zandonai, Aline Fraga [1 ]
Bonatto, Diego [2 ]
Machado, Denise Cantarelli [3 ]
Pegas Henriques, Joao Antonio [1 ,2 ,4 ]
机构：
[1] Univ Fed Rio Grande do Sul, Dept Biofis, Ctr Biotecnol, BR-91507970 Porto Alegre, RS, Brazil
[2] UCS, Inst Biotecnol, Caxias Do Sul, RS, Brazil
[3] Pontificia Univ Catolica Rio Grande do Sul, Dept Med Interna, Fac Med, Inst Pesquisas Biomed,Ctr Terapia Celular, Porto Alegre, RS, Brazil
[4] Univ Luterana Brasil, Lab Genet Toxicol, Canoas, RS, Brazil
来源：
DIFFERENTIATION | 2009年 / 77卷 / 03期
关键词：
Adipose-derived adult stem (ADAS) cells; Neuronal tissue; Neuronal differentiation; Neuronal markers; MARROW STROMAL CELLS; IN-VITRO DIFFERENTIATION; HUMAN BONE-MARROW; PROCESSED LIPOASPIRATE CELLS; NEURAL CELLS; ENDOTHELIAL-CELLS; PROGENITOR CELLS; LINEAGE CELLS; MOUSE; RAT;
D O I：
10.1016/j.diff.2008.10.016
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Adipose tissue contains many cells and proteins that are of value not only for their potential therapeutic applications, but also for the low cost of their harvest and delivery. Mesenchymal stem cells (MSC) were originally isolated from the bone marrow, although similar populations have been isolated from adipose and other tissues. At one time, neural tissues were not regarded as regenerative populations of cells. Therefore, the identification of cell populations capable of neuronal differentiation has generated immense interest. Adipose tissue may represent an alternative source of cells that are capable of neuronal differentiation, potentially enhancing its use in the treatment of neurological disease. The aim of this review is to cover the current state of knowledge of the differentiation potential of human adipose-derived stem (ADAS) cells, specifically their ability to give rise to neuronal cells in vitro. This review presents and discusses different protocols used for inducing human ADAS cells to differentiate in vitro, and the neuronal markers utilized in each system. (C) 2009 International Society of Differentiation. Published by Elsevier Ltd. All rights reserved.
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收藏
页码：221 / 228
页数：8
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