Precancerous lesions of the stomach, gastric cancer and hereditary gastric cancer syndromes

被引：161

作者：

Gullo, Irene ^{[1
,2
,3
,4
]}

Grillo, Federica ^{[5
,6
]}

Mastracci, Luca ^{[5
,6
]}

Vanoli, Alessandro ^{[7
,8
]}

Carneiro, Fatima ^{[1
,2
,3
,4
]}

Saragoni, Luca ^{[9
]}

Limarzi, Francesco ^{[10
]}

Ferro, Jacopo ^{[5
]}

Parente, Paola ^{[11
]}

Fassan, Matteo ^{[12
]}

机构：

[1] Ctr Hosp Univ Sao Joao CHUSJ, Dept Pathol, Porto, Portugal

[2] Univ Porto FMUP, Dept Pathol, Fac Med, Porto, Portugal

[3] Univ Porto Ipatimup, Inst Invest & Inovack Saude I3S, Porto, Portugal

[4] Univ Porto Ipatimup, Inst Mol Pathol & Immunol, Porto, Portugal

[5] Univ Genoa, Dept Surg Sci & Integrated Diagnost DICS, Anat Pathol Unit, Largo Rosanna Benzi 10, I-16132 Genoa, Italy

[6] IRCCS Oncol & Neurosci, Osped Policlin San Martino, Largo Rosanna Benzi 10, I-16132 Genoa, Italy

[7] Univ Pavia, Dept Mol Med, Anat Pathol Unit, Pavia, Italy

[8] Fdn IRCCS San Matteo Hosp, Pavia, Italy

[9] Osped GB Morgagni & L Pierantoni, UO Anat Patol, Forli, Italy

[10] Ist Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Biosci Lab, Meldola, FC, Italy

[11] Fdn IRCCS Osped Casa Sollievo Sofferenza, Pathol Unit, San Giovanni Rotondo, FG, Italy

[12] Univ Padua, Dept Med DIMED, Surg Pathol Unit, Padua, Italy

来源：

PATHOLOGICA | 2020年 / 112卷 / 03期

关键词：

gastric cancer; gastric dysplasia; gastric adenocarcinoma; hereditary gastric cancer syndromes; hereditary diffuse gastric cancer (HDGC); EPSTEIN-BARR-VIRUS; EXPRESSION-BASED CLASSIFICATION; INTESTINAL METAPLASIA; CLINICAL-PRACTICE; DIAGNOSTICALLY USEFUL; PROXIMAL POLYPOSIS; MOLECULAR SUBTYPES; CYSTICA PROFUNDA; CARCINOMA; DIFFUSE;

D O I：

10.32074/1591-951X-166

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Gastric cancer accounts for about 6% of cancers worldwide, being the fifth most frequently diagnosed malignancy and the third leading cause of cancer related death. Gastric carcinogenesis is a multistep and multifactorial process and is the result of the complex interplay between genetic susceptibility and environmental factors. The identification of predisposing conditions and of precancerous lesions is the basis for screening programs and early stage treatment. Furthermore, although most gastric cancers are sporadic, familial clustering is observed in up to 10% of patients. Among them, hereditary cases, related to known cancer susceptibility syndromes and/or genetic causes are thought to account for 1-3% of all gastric cancers. The pathology report of gastric resections specimens therefore requires a standardized approach as well as in depth knowledge of prognostic and treatment associated factors.

引用

页码：166 / 185

页数：20

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