Design and synthesis of new bidentate phosphoramidite ligands for enantioselective copper-catalyzed conjugate addition of diethylzinc to enones

被引：40

作者：

Boeda, Fabien ^{[1
]}

Rix, Diane ^{[1
]}

Clavier, Herve ^{[1
]}

Crevisy, Christophe ^{[1
]}

Mauduit, Marc ^{[1
]}

机构：

[1] Ecole Natl Super Chim Rennes, Equipe Synth Organises Syst Organises, UMR CNRS 6226, F-35700 Rennes, France

来源：

TETRAHEDRON-ASYMMETRY | 2006年 / 17卷 / 19期

关键词：

D O I：

10.1016/j.tetasy.2006.10.029

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Several thioaryl- and phosphino-phosphoramidite ligands have been synthesized from commercially available beta-aminoalcohols. This new family of bidentate ligands are highly active in the enantioselective copper-catalyzed conjugate addition of diethylzinc to both cyclic and acyclic enones showing moderate to good enantiomeric excesses of up to 81%. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：2726 / 2729

页数：4

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