Serum Krebs von den Lungen-6 level as a diagnostic biomarker for interstitial lung disease in Chinese patients

被引：48

作者：

Hu, Yang ^{[1
]}

Wang, Liu-Sheng ^{[1
]}

Jin, Yue-Ping ^{[1
]}

Du, Shan-Shan ^{[1
]}

Du, Yu-Kui ^{[1
]}

He, Xian ^{[1
]}

Weng, Dong ^{[1
]}

Zhou, Ying ^{[1
]}

Li, Qiu-Hong ^{[1
]}

Shen, Li ^{[1
]}

Zhang, Fen ^{[1
]}

Su, Yi-Liang ^{[1
]}

Sun, Xiao-Li ^{[1
]}

Ding, Jing-Jing ^{[2
]}

Zhang, Wen-Hui ^{[3
]}

Cai, Hou-Rong ^{[2
]}

Dai, Hua-Ping ^{[3
]}

Dai, Jing-Hong ^{[2
]}

Li, Hui-Ping ^{[1
]}

机构：

[1] Tongji Univ, Sch Med, Affiliated Hosp, Dept Resp Med,Shanghai Pulm Hosp, Shanghai, Peoples R China

[2] Nanjing Univ, Nanjing Drum Tower Hosp, Dept Resp Med, Sch Med, Nanjing 210008, Peoples R China

[3] Capital Med Univ, Beijing Chao Yang Hosp, Dept Resp & Crit Care Med, Affiliated Hosp, Beijing, Peoples R China

来源：

CLINICAL RESPIRATORY JOURNAL | 2017年 / 11卷 / 03期

关键词：

biomarker; diagnosis; interstitial lung disease; KL-6; prognosis; KL-6; CLASSIFICATION; EPIDEMIOLOGY; MANAGEMENT; MARKER; GUIDELINES; CRITERIA; MUCIN;

D O I：

10.1111/crj.12341

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

ObjectivesThe purpose of this study was to determine the diagnostic and prognostic values of serum KL-6 levels in Chinese patients with interstitial lung disease (ILDs). MethodsA total of 1084 subjects including 373 cases of ILDs, 584 cases of non-ILD pulmonary diseases, and 127 healthy individuals were recruited from three clinical centers in China between January 2011 and December 2013. A total of 106 patients undergoing treatments for ILDs in Shanghai Pulmonary Hospital between January 2011 and December 2013 were enrolled. Baseline and posttreatment serum KL-6 levels were determined. ResultsSerum KL-6 levels in patients with ILDs were significantly higher than those in patients with non-ILD pulmonary diseases or in healthy individuals (1492.092230.08 U/mL vs 258.67 +/- 268.73 U/mL or 178.73 +/- 71.17 U/mL, all P<0.05). At the cut-off value of 500 U/mL, the sensitivity and specificity of serum KL-6 as a diagnostic marker for ILDs was 77.75% and 94.51%, respectively. The Kappa value was 0.743 (P<0.001). The area below the receiver operating characteristic curve was 0.922 with a 95% Confidence interval of 0.904-0.941 (P<0.001). The posttreatment serum KL-6 levels significantly reduced in patients with improved ILDs, whereas markedly increased in patients with exacerbated ILDs (All P<0.05). ConclusionsSerum KL-6 levels might be a promising diagnostic biomarker for ILDs in Chinese patients. The prognostic value of serum KL-6 levels for ILDs remains to be verified by large-scaled studies.

引用

页码：337 / 345

页数：9

共 35 条

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