SIRT6 in Senescence and Aging-Related Cardiovascular Diseases

被引：58
作者：
Li, Xiaokang [1 ]
Liu, Lin [2 ]
Li, Tian [3 ]
Liu, Manling [3 ]
Wang, Yishi [3 ]
Ma, Heng [3 ]
Mu, Nan [3 ]
Wang, Haiyan [1 ]
机构：
[1] Fourth Mil Med Univ, China Tangdu Hosp, Dept Cardiol, Xian, Peoples R China
[2] Fourth Mil Med Univ, Dept Dermatol, Tangdu Hosp, Xian, Peoples R China
[3] Fourth Mil Med Univ, Dept Physiol & Pathophysiol, Sch Basic Med, Xian, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 09卷
基金：
中国国家自然科学基金;
关键词：
SIRT6; senescence; cardiovascular diseases; autophagy; oxidative stress; NF-KAPPA-B; VASCULAR OXIDATIVE STRESS; HISTONE DEACETYLASE SIRT6; DNA-DAMAGE RESPONSE; LOW-DENSITY-LIPOPROTEIN; ENDOTHELIAL-CELLS; LIFE-SPAN; PROTECTS CARDIOMYOCYTES; GENOMIC INSTABILITY; CHRONIC INFLAMMATION;
D O I：
10.3389/fcell.2021.641315
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
SIRT6 belongs to the nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylases and has established diverse roles in aging, metabolism and disease. Its function is similar to the Silent Information Regulator 2 (SIR2), which prolongs lifespan and regulates genomic stability, telomere integrity, transcription, and DNA repair. It has been demonstrated that increasing the sirtuin level through genetic manipulation extends the lifespan of yeast, nematodes and flies. Deficiency of SIRT6 induces chronic inflammation, autophagy disorder and telomere instability. Also, these cellular processes can lead to the occurrence and progression of cardiovascular diseases (CVDs), such as atherosclerosis, hypertrophic cardiomyopathy and heart failure. Herein, we discuss the implications of SIRT6 regulates multiple cellular processes in cell senescence and aging-related CVDs, and we summarize clinical application of SIRT6 agonists and possible therapeutic interventions in aging-related CVDs.
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页数：16
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共 215 条
[91]   The effect of caloric restriction on blood pressure and cardiovascular function: A systematic review and meta-analysis of randomized controlled trials [J].
Kirkham, Amy A. ;
Beka, Vanesa ;
Prado, Carla M. .
CLINICAL NUTRITION, 2021, 40 (03) :728-739
[92]   Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats [J].
Koltai, Erika ;
Szabo, Zsofia ;
Atalay, Mustafa ;
Boldogh, Istvan ;
Naito, Hisashi ;
Goto, Sataro ;
Nyakas, Csaba ;
Radak, Zsolt .
MECHANISMS OF AGEING AND DEVELOPMENT, 2010, 131 (01) :21-28
[93]   Nrf2 regulates ROS production by mitochondria and NADPH oxidase [J].
Kovac, Stjepana ;
Angelova, Plamena R. ;
Holmstroem, Kira M. ;
Zhang, Ying ;
Dinkova-Kostova, Albena T. ;
Abramov, Andrey Y. .
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2015, 1850 (04) :794-801
[94]   Chromatin and beyond: the multitasking roles for SIRT6 [J].
Kugel, Site ;
Mostoslavsky, Raul .
TRENDS IN BIOCHEMICAL SCIENCES, 2014, 39 (02) :72-81
[95]   RAP1 AND TELOMERE STRUCTURE REGULATE TELOMERE POSITION EFFECTS IN SACCHAROMYCES-CEREVISIAE [J].
KYRION, G ;
LIU, K ;
LIU, C ;
LUSTIG, AJ ;
LUSTIG, AJ .
GENES & DEVELOPMENT, 1993, 7 (7A) :1146-1159
[96]   Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1) [J].
Laity, John H. ;
Andrews, Glen K. .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2007, 463 (02) :201-210
[97]   Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises - Part II: The aging heart in health: Links to heart disease [J].
Lakatta, EG ;
Levy, D .
CIRCULATION, 2003, 107 (02) :346-354
[98]   mTOR signaling at a glance [J].
Laplante, Mathieu ;
Sabatini, David M. .
JOURNAL OF CELL SCIENCE, 2009, 122 (20) :3589-3594
[99]   Anti-Inflammatory Properties of Sirtuin 6 in Human Umbilical Vein Endothelial Cells [J].
Lappas, Martha .
MEDIATORS OF INFLAMMATION, 2012, 2012
[100]   Senescence-associated inflammatory responses: aging and cancer perspectives [J].
Lasry, Audrey ;
Ben-Neriah, Yinon .
TRENDS IN IMMUNOLOGY, 2015, 36 (04) :217-228
567891011121314