SIRT6 in Senescence and Aging-Related Cardiovascular Diseases

被引：58

作者：

Li, Xiaokang ^{[1
]}

Liu, Lin ^{[2
]}

Li, Tian ^{[3
]}

Liu, Manling ^{[3
]}

Wang, Yishi ^{[3
]}

Ma, Heng ^{[3
]}

Mu, Nan ^{[3
]}

Wang, Haiyan ^{[1
]}

机构：

[1] Fourth Mil Med Univ, China Tangdu Hosp, Dept Cardiol, Xian, Peoples R China

[2] Fourth Mil Med Univ, Dept Dermatol, Tangdu Hosp, Xian, Peoples R China

[3] Fourth Mil Med Univ, Dept Physiol & Pathophysiol, Sch Basic Med, Xian, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 09卷

基金：

中国国家自然科学基金;

关键词：

SIRT6; senescence; cardiovascular diseases; autophagy; oxidative stress; NF-KAPPA-B; VASCULAR OXIDATIVE STRESS; HISTONE DEACETYLASE SIRT6; DNA-DAMAGE RESPONSE; LOW-DENSITY-LIPOPROTEIN; ENDOTHELIAL-CELLS; LIFE-SPAN; PROTECTS CARDIOMYOCYTES; GENOMIC INSTABILITY; CHRONIC INFLAMMATION;

D O I：

10.3389/fcell.2021.641315

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

SIRT6 belongs to the nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylases and has established diverse roles in aging, metabolism and disease. Its function is similar to the Silent Information Regulator 2 (SIR2), which prolongs lifespan and regulates genomic stability, telomere integrity, transcription, and DNA repair. It has been demonstrated that increasing the sirtuin level through genetic manipulation extends the lifespan of yeast, nematodes and flies. Deficiency of SIRT6 induces chronic inflammation, autophagy disorder and telomere instability. Also, these cellular processes can lead to the occurrence and progression of cardiovascular diseases (CVDs), such as atherosclerosis, hypertrophic cardiomyopathy and heart failure. Herein, we discuss the implications of SIRT6 regulates multiple cellular processes in cell senescence and aging-related CVDs, and we summarize clinical application of SIRT6 agonists and possible therapeutic interventions in aging-related CVDs.

引用

页数：16

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