Elevated serum levels of C-reactive protein are associated with more severe psychopathology in a subgroup of patients with schizophrenia

被引:127
作者
Fan, Xiaoduo
Pristach, Cynthia
Liu, Emily Y.
Freudenreich, Oliver
Henderson, David C.
Goff, Donald C.
机构
[1] Massachusetts Gen Hosp, Schizophrenia Program, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Erie Cty Med Ctr & Labs, Dept Psychiat, Buffalo, NY 14215 USA
[4] SUNY Buffalo, Sch Med & Biol Sci, Buffalo, NY 14260 USA
[5] Womens & Childrens Hosp, Buffalo, NY USA
关键词
C-reactive protein; inflammation; schizophrenia; CEREBRAL BLOOD-FLOW; INFLAMMATORY RESPONSE SYSTEM; IL-1 RECEPTOR ANTAGONIST; PATIENTS RESISTANT; CSF LEVELS; INTERLEUKIN-2; NEUROLEPTICS; ALPHA; RISPERIDONE; DEPRESSION;
D O I
10.1016/j.psychres.2006.07.011
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The present study examined the hypothesis that elevated serum levels of C-reactive protein (CRP) would be associated with more severe clinical symptoms in patients with schizophrenia. Twenty-six inpatients with schizophrenia or schizoaffective disorder were enrolled. Serum levels of CRP were measured, and each patient was assessed with the Positive and Negative Syndrome Scale (PANSS). Subjects with CRP levels above the normal range (CRP > 0.50 mg/dl, elevated CRP group, N=5) scored significantly higher than those with CRP levels in the normal range (CRP <= 0.50 mg/dl, normal CRP group, N=21) on the PANSS total score, negative symptom subscale score and general psychopathology subscale score. There was no significant difference between the two groups on the PANSS positive symptom subscale score. An inflammatory process, as reflected by elevated serum levels of CRP, might be associated with more severe psychopathology in a subgroup of patients with schizophrenia. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:267 / 271
页数:5
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