Relationships Between Chemical Structure and Antioxidant Activity of Isolated Phytocompounds from Lemon Verbena

被引：55
作者：
Sanchez-Marzo, Noelia [1 ,2 ]
Lozano-Sanchez, Jesus [3 ,4 ]
de la Luz Cadiz-Gurrea, Maria [4 ,5 ]
Herranz-Lopez, Maria [1 ,2 ]
Micol, Vicente [1 ,2 ,6 ]
Segura-Carretero, Antonio [4 ,5 ]
机构：
[1] Univ Miguel Hernandez, IBMC, Elche 03202, Spain
[2] Univ Miguel Hernandez, Inst Invest Desarrollo & Innovac Biotecnol Sanita, Elche 03202, Spain
[3] Univ Granada, Dept Food Sci & Nutr, Campus Cartuja, E-18071 Granada, Spain
[4] PTS Granada, Res & Dev Funct Food Ctr CIDAF, Avda Conocimiento S-N,Edificio BioReg, Granada 18016, Spain
[5] Univ Granada, Dept Analyt Chem, C Fuentenueva S-N, E-18071 Granada, Spain
[6] Inst Salud Carlos III, CIBER CB12 03 30038, Fisiopatol Obesidad & Nutr, CIBERobn, Palma De Mallorca 07122, Spain
来源：
ANTIOXIDANTS | 2019年 / 8卷 / 08期
关键词：
lemon verbena; RP-HPLC-ESI-TOF-MS; semi-preparative chromatography; isolation; antioxidant; structure-activity relationship; TIME-OF-FLIGHT; PERFORMANCE LIQUID-CHROMATOGRAPHY; LIPPIA-CITRIODORA POLYPHENOLS; OXIDATIVE STRESS; ESSENTIAL OIL; COMPREHENSIVE CHARACTERIZATION; BIOACTIVE COMPOUNDS; PHENOLIC-COMPOUNDS; MASS-SPECTROMETRY; VERBASCOSIDE;
D O I：
10.3390/antiox8080324
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Over the last few years, people have been concerned about the narrow relationship between nutrition and health leading to an increasing demand of nutraceutical products and functional food. Lemon verbena (Lippia citriodora Kunth) has been traditionally used for respiratory, digestive, and muscular diseases, showing effects that are promoted by the antioxidant activity of its phytoconstituents. The antioxidant power of several lemon verbena extracts has been tested but its isolated compounds activity has not been described. The aim of the present work was to isolate phytochemicals from a commercial lemon verbena extract through a semi-preparative high-performance liquid chromatography approach for further evaluation of its individual antioxidant activity using three different methods. The structure-antioxidant activity relationships revealed the influence of substitutions in the strong antioxidant power exerted by glycosylated phenylpropanoids, in contrast to the low antioxidant capacity showed by iridoids. Development of enriched extracts in these compounds could lead to greater antioxidant effects and improved functional ingredients to prevent chronic diseases.
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页数：20
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