A new cytotoxic casbane diterpene from Euphorbia pekinensis

被引：60

作者：

Liang, Qiao-Li ^{[1
]}

Dai, Chuan-Chao ^{[2
]}

Jiang, Ji-Hong ^{[3
]}

Tang, Yu-Ping ^{[1
]}

Duan, Jin-Ao ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Key Lab TCM Formulae Res, Nanjing 210046, Peoples R China

[2] Nanjing Normal Univ, Dept Life Sci, Nanjing 210038, Peoples R China

[3] Key Lab Biotechnol Med Plants Jiangsu Prov, Nanjing 211153, Peoples R China

来源：

FITOTERAPIA | 2009年 / 80卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Euphorbia pekinensis; Casbane diterpene; Pekinenal; 5 alpha-hydroxy-1 beta H; 2 alpha H-casba-3Z; 7E; 11E-triene-18-al; Cytotoxic; X-ray; SPURGE FAMILY EUPHORBIACEAE; 1ST INSIGHTS; IRRITANT; ESTERS; PRINCIPLES; INHIBITORS; AGENTS;

D O I：

10.1016/j.fitote.2009.06.014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new cytotoxic casbane diterpene, named pekinenal, was isolated from the roots of Euphorbia pekinensis. Its structure was elucidated as 5 alpha-hydroxy-1 beta H,2 alpha H-casba-3Z,7E,11E-triene-18-al by a combination of 1D- and 2D-NMR techniques and confirmed by X-ray crystallography. Pekinenal showed cytotoxic activity against all four human cancer cell lines tested. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：514 / 516

页数：3

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