Catalytic asymmetric three-component acyl-Strecker reaction

被引：93

作者：

Pan, Subhas Chandra ^{[1
]}

List, Benjamin ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 06期

关键词：

D O I：

10.1021/ol0702674

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first organocatalytic asymmetric three-component Strecker reaction, the urea-catalyzed acylcyanation of in situ generated imines, has been developed. Different alpha-amido nitriles are formed in excellent yields and enantioslectivities from aldehydes, amines, and acyl cyanides in the presence of Jacobsen's thiourea catalyst 5. Despite its obvious use for the synthesis of alpha-amino acids and their derivatives, our reaction may find use in diversity oriented synthesis and medicinal chemistry.

引用

页码：1149 / 1151

页数：3

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