Glucagon Control on Food Intake and Energy Balance

被引:50
作者
Al-Massadi, Omar [1 ]
Ferno, Johan [2 ]
Dieguez, Carlos [3 ,4 ]
Nogueiras, Ruben [3 ,4 ]
Quinones, Mar [3 ,4 ]
机构
[1] Sorbonne Univ, Inserm UMR S1270, Fac Sci & Ingn, Inst Fer Moulin, F-75005 Paris, France
[2] Haukeland Hosp, Hormone Lab, N-5020 Bergen, Norway
[3] Univ Santiago de Compostela, Inst Invest Sanitaria, CIMUS, Dept Physiol, Santiago De Compostela 15782, Spain
[4] CIBER Fisiopatol Obesidad & Nutr CIBERobn, Santiago De Compostela 15706, Spain
关键词
glucagon; energy balance; food intake; body weight; energy expenditure; thermogenesis; lipid metabolism; obesity; FATTY-ACID-METABOLISM; TRIPLE-ACTING AGONIST; SPONTANEOUS MEAL SIZE; CORRECTS OBESITY; HYBRID PEPTIDE; BODY-WEIGHT; INSULIN; RECEPTOR; GLP-1; HORMONE;
D O I
10.3390/ijms20163905
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glucagon exerts pleiotropic actions on energy balance and has emerged as an attractive target for the treatment of diabetes and obesity in the last few years. Glucagon reduces body weight and adiposity by suppression of appetite and by modulation of lipid metabolism. Moreover, this hormone promotes weight loss by activation of energy expenditure and thermogenesis. In this review, we cover these metabolic actions elicited by glucagon beyond its canonical regulation of glucose metabolism. In addition, we discuss recent developments of therapeutic approaches in the treatment of obesity and diabetes by dual- and tri-agonist molecules based on combinations of glucagon with other peptides. New strategies using these unimolecular polyagonists targeting the glucagon receptor (GCGR), have become successful approaches to evaluate the multifaceted nature of glucagon signaling in energy balance and metabolic syndrome.
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页数:12
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