The role of hyperthermia as a treatment for non-muscle invasive bladder cancer

被引:8
作者
Bahouth, Zaher [1 ]
Halachmi, Sarel [1 ]
Moskovitz, Boaz [1 ]
Nativ, Ofer [1 ]
机构
[1] Technion Israel Inst Technol, Fac Med, Dept Urol, Bnai Zion Med Ctr, Haifa, Israel
关键词
Radiofrequency induced chemotherapy effect (RITE); non-muscle invasive bladder cancer; hyperthermia; mitomycin C; chemo-hyperthermia; intravesical chemotherapy; BACILLUS-CALMETTE-GUERIN; CARCINOMA IN-SITU; LOCAL MICROWAVE HYPERTHERMIA; TRANSITIONAL-CELL CARCINOMA; INTRAVESICAL MITOMYCIN-C; PHASE-II TRIAL; UROTHELIAL CARCINOMA; THERMO-CHEMOTHERAPY; URINARY-BLADDER; RISK;
D O I
10.1586/14737140.2016.1126515
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Non-muscle invasive bladder cancer (NMIBC) has a high tendency for recurrence and progression. Currently, all known intravesical agents are associated with adverse effects (AEs) and limited efficacy. The combination of hyperthermia (HT) with intravesical Mitomycin C (MMC) chemotherapy has been shown to improve outcomes. The added efficacy of HT to MMC was first shown in preclinical studies. The reports on patients with NMIBC have indicated that the treatment is safe and well tolerated. Several clinical studies reported the efficacy of radiofrequency-induced chemotherapy effect (RITE) in the treatment of patients with NMIBC. This modality was shown to be superior to MMC alone. RITE was effective also in patients with high-risk NMIBC, including those who failed Bacillus Calmette-Guerin (BCG). This study provides an updated review of literature regarding the use of RITE in patients with NMIBC.
引用
收藏
页码:189 / 198
页数:10
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