Propofol effects on cerebellar long-term depression

被引：5

作者：

Lee, Kwan Young ^{[1
,2
]}

Kim, Young Im ^{[1
,3
]}

Kim, Se Hoon ^{[1
]}

Park, Hyung Seo ^{[1
]}

Park, Youn Joon ^{[4
]}

Ha, Myung Sook ^{[5
,6
]}

Jin, Yunju ^{[7
]}

Kim, Dong Kwan ^{[1
,6
]}

机构：

[1] Konyang Univ, Dept Physiol, Coll Med, Daejeon 302718, South Korea

[2] Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL USA

[3] Yeosu Chonnam Hosp, Dept Anesthesiol, Yeosu, South Korea

[4] Dankook Univ, Coll Med, Dept Pediat Surg, Cheonan, South Korea

[5] Konyang Univ Hosp, Dept Ophthalmol, Daejeon, South Korea

[6] Konyang Univ, Coll Med, Myunggok Med Res Inst, Daejeon, South Korea

[7] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

来源：

NEUROSCIENCE LETTERS | 2015年 / 609卷

基金：

新加坡国家研究基金会;

关键词：

Cerebellum; Metabotropic glutamate receptor 1; Long-term depression; Propofol; Purkinje cell; Parallel fiber; DELTA-2; GLUTAMATE-RECEPTOR; MOVEMENT-DISORDERS; PURKINJE-CELLS; MUTANT MICE; MGLUR1; PLASTICITY; TRANSMISSION; MECHANISMS; MYOCLONUS; SLICES;

D O I：

10.1016/j.neulet.2015.09.037

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Propofol is an intravenously administered anesthetic that induces gamma-aminobutyric acid-mediated inhibition in the central nervous system. It has been implicated in prolonged movement disorders. Since the cerebellum is important for motor coordination and learning, we investigated the potential effects of propofol on cerebellar circuitry. Using the whole-cell patch-clamp technique in Wister rat cerebellar slices, we demonstrated that propofol administration impaired long-term depression from the parallel fiber (PF) to Purkinje cell (PC) synapses (PF-LTD). Also, propofol reduced metabotropic glutamate receptor 1 (mGluR1)-mediated and group I mGluR agonist-induced slow currents in PCs. These results suggest that the propofol-induced PF-LTD impairment may be related to an alteration in mGluR1 signaling, which is essential to motor learning. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：18 / 22

页数：5

共 28 条

[1] REDUCED HIPPOCAMPAL LONG-TERM POTENTIATION AND CONTEXT-SPECIFIC DEFICIT IN ASSOCIATIVE LEARNING IN MGLUR1 MUTANT MICE [J].