A palladium-catalyzed three-component cascade S-transfer reaction in ionic liquids

被引：38

作者：

Li, Jianxiao ^{[1
]}

Wu, Yaodan ^{[1
]}

Hu, Miao ^{[1
]}

Li, Can ^{[1
]}

Li, Meng ^{[1
]}

He, Dandan ^{[1
]}

Jiang, Huanfeng ^{[1
]}

机构：

[1] South China Univ Technol, Key Lab Funct Mol Engn Guangdong Prov, Sch Chem & Chem Engn, Guangzhou 510640, Guangdong, Peoples R China

来源：

GREEN CHEMISTRY | 2019年 / 21卷 / 15期

基金：

中国国家自然科学基金;

关键词：

SULFENYLATED CARBONYL-COMPOUNDS; CROSS-COUPLING REACTION; TRANSITION-METAL-FREE; THIOL-FREE SYNTHESIS; ARYL BORONIC ACIDS; C-S; BOND FORMATION; EFFICIENT SYNTHESIS; PROPARGYLIC ALCOHOLS; POTASSIUM SULFIDE;

D O I：

10.1039/c9gc01718f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A palladium-catalyzed three component cascade S-transfer reaction of acetylinic oximes with aryl halides using readily available Na2S2O3 as an odorless sulfenylation reagent under aerobic conditions in ionic liquids was described. The present protocol features environmental friendliness, good functional group compatibility, odorless sulfenylation reagents, without any ligand or additive, and excellent atom and step economy. Remarkably, this cascade procedure will be bringing about further late-stage modification for the construction of structurally complex isoxazole scaffolds in synthetic and pharmaceutical chemistry.

引用

收藏

页码：4084 / 4089

页数：6

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