Cardiac amyloidosis

被引:4
作者
Poullot, Elsa [1 ,2 ]
Oghina, Silvia [2 ,3 ]
Kalsoum, Sarah [1 ,2 ]
Damy, Thibaud [2 ,3 ]
机构
[1] GHU Henri Mondor, AP HP, Dept Pathol, 51 Ave Marechal de Lattre de Tassigny, F-94010 Creteil, France
[2] GHU Henri Mondor, AP HP, Reseau Cardiogen, Ctr Francais Reference Amylose Cardiaque CRAC, Creteil, France
[3] GHU Henri Mondor, AP HP, Dept Cardiol, Creteil, France
关键词
Cardiac amyloidosis; ATTR amyloidosis; Transthyretin; AL arnyloidosis; Endomyocardial biopsy; Mass spectrometry;
D O I
10.1016/j.annpat.2020.11.010
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Different types of amyloid deposits involve the heart. Transthyretin and light chain amyloidosis are the most frequent. Diagnostic performance, typing and treatments have improved in the last decade, and prognosis of cardiac amyloidosis is now significantly better thanks to targeted therapies. In this article, we will describe the clinical manifestations of cardiac amyloidosis, the diagnostic approach and detail the characteristics and specific treatments of the most frequent types of cardiac amyloidosis. We will focus on the histopathological aspects, especially on the importance of amyloid typing. (C) 2020 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:25 / 37
页数:13
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