pH-Sensitive Delivery Vehicle Based on Folic Acid-Conjugated Polydopamine-Modified Mesoporous Silica Nanoparticles for Targeted Cancer Therapy

被引：407

作者：

Cheng, Wei ^{[1
,2
,3
]}

Nie, Junpeng ^{[2
,3
]}

Xu, Lv ^{[2
,3
]}

Liang, Chaoyu ^{[1
,2
,3
]}

Peng, Yunmei ^{[2
,3
]}

Liu, Gan ^{[2
,3
]}

Wang, Teng ^{[1
,2
,3
]}

Mei, Lin ^{[2
,3
]}

Huang, Laiqiang ^{[1
,2
,3
]}

Zeng, Xiaowei ^{[1
,2
,3
]}

机构：

[1] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China

[2] Tsinghua Univ, Shenzhen Key Lab Gene & Antibody Therapy, Minist Prov Jointly Construct Base State Key Lab, Shenzhen Key Lab Chem Biol, Shenzhen 518055, Peoples R China

[3] Tsinghua Univ, Div Life & Hlth Sci, Grad Sch Shenzhen, Shenzhen 518055, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2017年 / 9卷 / 22期

基金：

中国国家自然科学基金;

关键词：

nanomedicine; mesoporous silica; surface modification; pH-sensitive delivery; cancer targeting; ANTICANCER DRUG-DELIVERY; VITAMIN-E TPGS; SURFACE MODIFICATION; MAGNETIC NANOPARTICLES; CONTROLLED-RELEASE; INSULIN DELIVERY; FOLATE RECEPTOR; CELLULAR UPTAKE; CORE-SHELL; IN-VITRO;

D O I：

10.1021/acsami.7b02457

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In this study, we introduced,a targeting polymer poly(ethylene glycol) folic acid (PEG FA) on the surface of polyclopatnine (PDA)modified mesoporous silica nanoparticles (MSNs) to develop the novel nanoparticles (NPs) MSNs@PDA-PEGHFA, which were employed as a drug delivery system loaded with doxorubicin (DOX) as a model drug for cervical cancer therapy. The chemical structure and properties of these NPs were characterized by transmission electron microscopy, X-ray photoelectron spectroscopy) N-2 adsorption/desorption, dynamic light scattering-autosizer, thermogravimetric analysis, and Fourier transform infrared spectroscopy. The pH-sensitive PDA coating served as a gatekeeper. The in vitro drug release experiments showed pH-dependent and 'sustained drug,release profiles that could enhance the therapeutic anticancer effect and minimize potential damage to normal cells due to the acidic microenvironment of theitumor. These MSN5@PDA-PEG-FA achieved significantly high targeting efficiency, which was demonstrated by the in vitro Cellular uptake and cellular targeting assay. Compared with that of free DOX and DOX, loaded NPs without the folic targeting ligakl, the FA-targeted NPs exhibited higher antitumor efficky in vivo) implying that they are a highly promising potential carrier for cancer treatments.

引用

页码：18462 / 18473

页数：12

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