Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice

被引：148

作者：

Jang, Youngmok C. ^{[1
,2
]}

Perez, Viviana I. ^{[1
,2
]}

Song, Wook ^{[1
,2
]}

Lustgarten, Michael S. ^{[1
,3
]}

Salmon, Adam B. ^{[1
]}

Mele, James ^{[1
,3
]}

Qi, Wenbo ^{[1
,2
]}

Liu, Yuhong ^{[1
,2
]}

Liang, Hanyu ^{[1
,2
]}

Chaudhuri, Asish ^{[1
,4
,5
]}

Ikeno, Yuji ^{[1
,2
,5
]}

Epstein, Charles J. ^{[6
,7
]}

Van Remmen, Holly ^{[1
,2
,5
]}

Richardson, Arlan ^{[1
,2
,5
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Sam & Ann Barshop Inst Longev & Aging Studies, San Antonio, TX 78245 USA

[2] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78245 USA

[3] Univ Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78245 USA

[4] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78245 USA

[5] GRECC, San Antonio, TX USA

[6] Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94143 USA

[7] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2009年 / 64卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Oxidative damage; Mn superoxide dismutase; Pathology; Aging; SKELETAL-MUSCLE ATROPHY; OXIDATIVE STRESS; CAENORHABDITIS-ELEGANS; FLUOROMETRIC-DETERMINATION; CALORIE RESTRICTION; STATIONARY-PHASE; GENE-EXPRESSION; REACTIVE OXYGEN; KNOCKOUT MOUSE; LONGEVITY;

D O I：

10.1093/gerona/glp100

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Genetic manipulations of Mn superoxide dismutase (MnSOD), SOD2 expression have demonstrated that altering the level of MnSOD activity is critical for cellular function and life span in invertebrates. In mammals, Sod2 homozygous knockout mice die shortly after birth, and alterations of MnSOD levels are correlated with changes in oxidative damage and in the generation of mitochondrial reactive oxygen species. In this study, we directly tested the effects of overexpressing MnSOD in young (4-6 months) and old (26-28 months) mice on mitochondrial function, levels of oxidative damage or stress, life span, and end-of-life pathology. Our data show that an approximately twofold overexpression of MnSOD throughout life in mice resulted in decreased lipid peroxidation, increased resistance against paraquat-induced oxidative stress, and decreased age-related decline in mitochondrial ATP production. However. this change in MnSOD expression did not alter either life span or age-related pathology.

引用

页码：1114 / 1125

页数：12

共 67 条

[61] Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress [J].