Life-Threatening Extreme Methemoglobinemia during Standard Dose Nitric Oxide Therapy

被引：13
作者：
Centorrino, Roberta [1 ]
Shankar-Aguilera, Shivani [1 ]
Foligno, Silvia [1 ]
De Luca, Daniele [1 ,2 ]
机构：
[1] South Paris Univ Hosp, AP HP, A Beclere Med Ctr, Div Pediat & Neonatal Crit Care, Paris, France
[2] South Paris Saclay Univ, INSERM, U999, Physiopathol & Therapeut Innovat Unit, Paris, France
来源：
NEONATOLOGY | 2019年 / 116卷 / 03期
关键词：
Methemoglobinemia; Nitric oxide; Iloprost; Sildenafil; Standard dose; PRETERM INFANTS; ILOPROST;
D O I：
10.1159/000501462
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
We report the first case of life-threatening extreme neonatal-acquired methemoglobinemia that occurred during inhaled nitric oxide (iNO) at the standard 20 ppm dose in a neonate with early onset sepsis and suprasystemic pulmonary hypertension. Life-threatening methemoglobinemia has been efficaciously treated with methylene blue and ascorbic acid, while stopping iNO and starting iloprost and sildenafil. The patient was subjected to various tests (including gene sequencing and hemoglobin electrophoresis) and did not have any known genetic cause or predisposition for methemoglobinemia. Neuroimaging and the 2-year clinical follow-up were completely normal.
引用
收藏
页码：295 / 298
页数：4
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