Anakinra for Myocarditis in Juvenile Idiopathic Arthritis

被引：0
|
作者：
Movva, Rajesh [1 ]
Brown, Suzanne B. [1 ]
Morris, D. Lynn [1 ,2 ]
Figueredo, Vincent M. [1 ,2 ]
机构：
[1] Albert Einstein Med Ctr, Div Cardiol, Philadelphia, PA 19141 USA
[2] Thomas Jefferson Univ, Jefferson Med Coll, Dept Med, Philadelphia, PA 19107 USA
来源：
TEXAS HEART INSTITUTE JOURNAL | 2013年 / 40卷 / 05期
关键词：
Anti-inflammatory agents/therapeutic use; antirheumatic agents/therapeutic use; arthritis; juvenile rheumatoid/complications/drug therapy; disease susceptibility; heart/drug effects; interferon-beta/therapeutic use; interleukin 1 receptor antagonist protein; myocarditis/diagnosis; treatment outcome; ventricular dysfunction; left/drug effects; LEFT-VENTRICULAR FUNCTION; RECEPTOR ANTAGONIST; HEART-FAILURE; INTERLEUKIN-1; THERAPY; GLOBULIN; BLOCKADE; ALPHA;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 20-year-old pregnant woman with a history of juvenile idiopathic arthritis presented with flu-like symptoms, systemic inflammation with myocarditis, and severe cardiomyopathy. Six weeks earlier, her chronic-arthritis therapy had been changed from anakinra, an interleukin-1 beta receptor antagonist, to etanercept When she resumed taking anakinra, her condition improved dramatically, including a complete recovery of ventricular function. Myocarditis is a well-recognized complication of systemic vasculitides. This unusual case emphasizes the important pathophysiologic role of interleukin receptors in the successful treatment of myocarditis. We suggest that clinical cardiologists be aware of the therapeutic usefulness of biological agents such as anakinra in patients with rheumatic conditions.
引用
收藏
页码：623 / 625
页数：3
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