Pref-1 and adipokine expression in adipose tissues of GK and Zucker rats

被引：24
作者：
Barbu, Andreea [1 ]
Hedlund, Gabriella Persdotter [2 ]
Lind, Jenny [1 ]
Carlsson, Carina [1 ]
机构：
[1] BMC, Dept Med Cell Biol, S-75123 Uppsala, Sweden
[2] Uppsala Univ, Dept Neurosci, S-75124 Uppsala, Sweden
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2009年 / 299卷 / 02期
关键词：
Adipokines; Adipocytes; Fat; Diabetes; Pref-1; Goto Kakizaki; Zucker; FETAL ANTIGEN 1; INSULIN-RESISTANT; GROWTH-HORMONE; LEPTIN LEVELS; PROTEIN; GENE; FAT; INFLAMMATION; ADIPONECTIN; OBESITY;
D O I：
10.1016/j.mce.2008.11.019
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In view of the central role of preadipocyte factor-1, adiponectin and leptin in white adipose tissue function, the aim of the present study was to analyze the mRNA expression of these proteins and of the inflammatory markers interleukin-6 and tumor necrosis factor-a in visceral and subcutaneous fat pads of rats with different metabolic disorders. We demonstrated highly divergent expression of preadipocyte factor-1, upregulated expression of adiponectin, interleukin-6 and TNF-alpha mRNA in adipose tissues of the diabetic Goto Kakizaki rat compared to the obese Zucker rat. This was correlated to an increased number of large adipocytes and serum levels of adiponectin. Furthermore, in all four strains studied (as above plus Wistar Furth and Zucker Lean), significant heterogeneity was evident in adipokine expression within specific adipose tissues previously defined as belonging to the visceral or subcutaneous fat depots. These results suggest that significantly increased levels of inflammation and redistribution of adipocyte size are mechanisms contributing to the development of type 2 diabetes in the GK rat. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：163 / 171
页数：9
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