EGFR-Mutated Lung Cancer With T790M-Acquired Resistance in the Brain and Histologic Transformation in the Lung

被引：33

作者：

Scher, Kevin S. ^{[1
]}

Saldivar, Juan-Sebastian ^{[1
]}

Fishbein, Michael ^{[2
]}

Marchevsky, Alberto ^{[3
]}

Reckamp, Karen L. ^{[1
]}

机构：

[1] City Hope Comprehens Canc Ctr, Duarte, CA USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

[3] Cedars Sinai Med Ctr, Hollywood, CA USA

来源：

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK | 2013年 / 11卷 / 09期

关键词：

ERLOTINIB; GEFITINIB;

D O I：

10.6004/jnccn.2013.0126

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This case report describes the rare occurrence of a T790M resistance mutation found in a central nervous system (CNS) parenchymal metastasis. A concomitant squamous histology transformation in a lung non-T790M-resistant metastasis is also described. The authors hypothesize that this CNS resistance and histology transformation may have resulted from intermittent use of erlotinib treatment. This case report emphasizes the complexities of using erlotinib in the induction setting.

引用

页码：1040 / 1044

页数：5

共 22 条

[1]

Blay JY, 2007, J CLIN ONCOL, V25, P1107, DOI 10.1200/JCO.2006.09.0183

[2] Optimization of Dosing for EGFR-Mutant Non-Small Cell Lung Cancer with Evolutionary Cancer Modeling [J].

Chmielecki, Juliann ;

Foo, Jasmine ;

Oxnard, Geoffrey R. ;

Hutchinson, Katherine ;

Ohashi, Kadoaki ;

Somwar, Romel ;

Wang, Lu ;

Amato, Katherine R. ;

Arcila, Maria ;

Sos, Martin L. ;

Socci, Nicholas D. ;

Viale, Agnes ;

de Stanchina, Elisa ;

Ginsberg, Michelle S. ;

Thomas, Roman K. ;

Kris, Mark G. ;

Inoue, Akira ;

Ladanyi, Marc ;

Miller, Vincent A. ;

Michor, Franziska ;

Pao, William .

SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (90)

[3] Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing [J].

Gerlinger, Marco ;

Rowan, Andrew J. ;

Horswell, Stuart ;

Larkin, James ;

Endesfelder, David ;

Gronroos, Eva ;

Martinez, Pierre ;

Matthews, Nicholas ;

Stewart, Aengus ;

Tarpey, Patrick ;

Varela, Ignacio ;

Phillimore, Benjamin ;

Begum, Sharmin ;

McDonald, Neil Q. ;

Butler, Adam ;

Jones, David ;

Raine, Keiran ;

Latimer, Calli ;

Santos, Claudio R. ;

Nohadani, Mahrokh ;

Eklund, Aron C. ;

Spencer-Dene, Bradley ;

Clark, Graham ;

Pickering, Lisa ;

Stamp, Gordon ;

Gore, Martin ;

Szallasi, Zoltan ;

Downward, Julian ;

Futreal, P. Andrew ;

Swanton, Charles .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (10) :883-892

[4] A phase III randomized, double-blind, placebo-controlled trial of the epidermal growth factor receptor inhibitor gefitinb in completely resected stage IB-IIIA non-small cell lung cancer (NSCLC): NCIC CTG BR.19 [J].

Goss, G. D. ;

Lorimer, I. ;

Tsao, M. S. ;

O'Callaghan, C. J. ;

Ding, K. ;

Masters, G. A. ;

Roberts, P. ;

Jett, J. R. ;

Edelman, M. J. ;

Shepherd, F. A. .

JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (18)

[5] Rebiopsy of Non-Small Cell Lung Cancer Patients With Acquired Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor [J].

Hata, Akito ;

Katakami, Nobuyuki ;

Yoshioka, Hiroshige ;

Takeshita, Jumpei ;

Tanaka, Kosuke ;

Nanjo, Shigeki ;

Fujita, Shiro ;

Kaji, Reiko ;

Imai, Yukihiro ;

Monden, Kazuya ;

Matsumoto, Takeshi ;

Nagata, Kazuma ;

Otsuka, Kyoko ;

Tachikawa, Ryo ;

Tomii, Keisuke ;

Kunimasa, Kei ;

Iwasaku, Masahiro ;

Nishiyama, Akihiro ;

Ishida, Tadashi ;

Nishimura, Yoshihiro .

CANCER, 2013, 119 (24) :4325-4332

[6] Response and resistance in a non-small-cell lung cancer patient with an epidermal growth factor receptor mutation and leptomeningeal metastases treated with high-dose gefitinib [J].

Jackman, David M. ;

Holmes, Alison J. ;

Lindeman, Neal ;

Wen, Patrick Y. ;

Kesari, Santosh ;

Borras, Ana M. ;

Bailey, Christopher ;

de Jong, Francisca ;

Jaenne, Pasi A. ;

Johnson, Bruce E. .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (27) :4517-4520

[7] Impact on Disease-Free Survival of Adjuvant Erlotinib or Gefitinib in Patients with Resected Lung Adenocarcinomas that Harbor EGFR Mutations [J].

Janjigian, Yelena Y. ;

Park, Bernard J. ;

Zakowski, Maureen F. ;

Ladanyi, Marc ;

Pao, William ;

D'Angelo, Sandra P. ;

Kris, Mark G. ;

Shen, Ronglai ;

Zheng, Junting ;

Azzoli, Christopher G. .

JOURNAL OF THORACIC ONCOLOGY, 2011, 6 (03) :569-575

[8] Neoadjuvant (induction) erlotinib response in stage IIIA non-small-cell lung cancer [J].

Kappers, Ingrid ;

Klomp, Houke M. ;

Burgers, Jacobus A. ;

Van Zandwijk, Nico ;

Haas, Rick L. M. ;

van Pel, Renee .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (25) :4205-4207

[9] Identification of non-small-cell lung cancer with activating EGFR mutations in malignant effusion and cerebrospinal fluid: Rapid and sensitive detection of exon 19 deletion E746-A750 and exon 21 L858R mutation by immunocytochemistry [J].

Kawahara, Akihiko ;

Azuma, Koichi ;

Sumi, Akiko ;

Taira, Tomoki ;

Nakashima, Kazutaka ;

Aikawa, Emiko ;

Abe, Hideyuki ;

Yamaguchi, Tomohiko ;

Takamori, Shinzo ;

Akiba, Jun ;

Kage, Masayoshi .

LUNG CANCER, 2011, 74 (01) :35-40

[10] Phase III trial of maintenance gefitinib or placebo after concurrent chemoradiotherapy and docetaxel consolidation in inoperable stage III non-small-cell lung cancer: SWOG S0023 [J].

Kelly, Karen ;

Chansky, Kari ;

Gaspar, Laurie E. ;

Albain, Kathy S. ;

Jett, James ;

Ung, Yee C. ;

Lau, Derick H. M. ;

Crowley, John J. ;

Gandara, David R. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15) :2450-2456

← 1 2 3 →