Total Synthesis of (+)-Pleuromutilin

被引：70

作者：

Fazakerley, Neal J. ^{[1
]}

Helm, Matthew D. ^{[1
]}

Procter, David J. ^{[1
]}

机构：

[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 21期

基金：

英国工程与自然科学研究理事会;

关键词：

natural products; pleuromutilin; radicals; samarium; total synthesis; ELECTRON-TRANSFER REDUCTION; SAMARIUM DIIODIDE; ORGANOZINC REAGENTS; SECONDARY ALCOHOLS; CARBONYL-COMPOUNDS; PLEUROMUTILIN; DERIVATIVES; ANTIBIOTICS; CHEMISTRY; IODIDE;

D O I：

10.1002/chem.201300968

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first enantiospecific total synthesis of the antibacterial natural product (+)-pleuromutilin has been achieved. The approach includes the synthesis of a non-racemic cyclisation substrate from (+)-trans-dihydrocarvone, a highly selective SmI2-mediated cyclisation cascade, an electron transfer reduction of a hindered ester, and the first efficient conversion of (+)-mutilin to the target.

引用

页码：6718 / 6723

页数：6

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