Efficacy of chemotherapy after progression with nivolumab in squamous cell carcinoma of the head and neck

被引：7
|
作者：
Suzuki, Shinsuke [1 ]
Toyoma, Satoshi [1 ]
Tomizawa, Hiroki [1 ]
Yamada, Toshiki [1 ]
Iikawa, Nobuko [1 ]
Shiina, Kazuhiro [1 ]
Saito, Hidekazu [1 ]
Koizumi, Koh [1 ]
Kawasaki, Yohei [1 ]
Yamada, Takechiyo [1 ]
机构：
[1] Akita Univ, Dept Otorhinolaryngol & Head & Neck Surg, Grad Sch Med, Akita 0108543, Japan
来源：
AURIS NASUS LARYNX | 2020年 / 47卷 / 03期
关键词：
Head and neck squamous cell carcinoma; Immune checkpoint inhibitor; Nivolumab; Chemotherapy; Recurrence; Metastasis; INVESTIGATORS CHOICE; RESPONSE RATES; RECURRENT; INHIBITORS; CETUXIMAB; THERAPY; CANCER; TRIAL;
D O I：
10.1016/j.anl.2019.06.004
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Nivolumab, a programmed death-1 (PD-1) inhibitor, has shown promising results against squamous cell carcinoma of the head and neck (SCCHN) in cases of recurrence or in a metastatic setting after platinum-based therapy. However, treatment alternatives for patients with nivolumab-refractory are limited, and a constant opinion is not provided. Recently, accumulating studies have demonstrated that chemotherapy after immune checkpoint inhibitor treatment may induce better objective responses in patients with advanced non-small cell lung cancer. However, there are few reports on the increased effect of chemotherapy after nivolumab treatment in SCCHN. Therefore, cases must be accumulated to identify patients with nivolumab-refractory SCCHN who may benefit from chemotherapy. Here, we present patients with SCCHN who exhibited a significant response to chemotherapy after nivolumab treatment. (C) 2019 Elsevier B.V. All rights reserved.
引用
收藏
页码：485 / 488
页数：4
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