Inhibition of monoamine oxidase B in the brains of smokers

被引：531

作者：

Fowler, JS ^{[1
]}

Volkow, ND ^{[1
]}

Wang, GJ ^{[1
]}

Pappas, N ^{[1
]}

Logan, J ^{[1
]}

MacGregor, R ^{[1
]}

Alexoff, D ^{[1
]}

Shea, C ^{[1
]}

Schlyer, D ^{[1
]}

Wolf, AP ^{[1
]}

Warner, D ^{[1
]}

Zezulkova, I ^{[1
]}

Cilento, R ^{[1
]}

机构：

[1] SUNY STONY BROOK,DEPT PSYCHIAT,STONY BROOK,NY 11794

来源：

NATURE | 1996年 / 379卷 / 6567期

关键词：

D O I：

10.1038/379733a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

THE massive health problem associated with cigarette smoking is exacerbated by the addictive properties of tobacco smoke and the limited success of current approaches to cessation of smoking(1). Yet little is known about the neuropharmacological actions of cigarette smoke that contribute to smoking behaviour, or why smoking is so prevalent in psychiatric disorders(2) and is associated with a decreased risk of Parkinson's disease(3), Here we report that brains of living smokers show a 40% decrease in the level of monoamine oxidase B (MAO B; EC 1.4.3.4) relative to non-smokers or former smokers. MAO B is involved in the breakdown of dopamine, a neurotransmitter implicated in reinforcing and motivating behaviours as well as movement. MAO B inhibition is therefore associated with enhanced activity of dopamine(4), as well as with decreased production of hydrogen peroxide, a source of reactive oxygen species 5, We propose that reduction of MAO B activity may synergize with nicotine to produce the diverse behavioural and epidemiological effects of smoking.

引用

页码：733 / 736

页数：4

共 31 条

[1] A REVERSIBLE MONOAMINE-OXIDASE-A INHIBITOR (MOCLOBEMIDE) FACILITATES SMOKING CESSATION AND ABSTINENCE IN HEAVY, DEPENDENT SMOKERS [J].