Synthesis of 1-(5-amino-3,5-dideoxy-3-methoxycarbonylmethyl-β-D-ribofuranosyl)thymine

被引：7

作者：

Lu, DM ^{[1
]}

Min, JM ^{[1
]}

Zhang, LH ^{[1
]}

机构：

[1] Beijing Med Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

来源：

CARBOHYDRATE RESEARCH | 1999年 / 317卷 / 1-4期

基金：

中国国家自然科学基金;

关键词：

thymidine analogue; oligonucleotides; stereoselective synthesis;

D O I：

10.1016/S0008-6215(99)00057-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to synthesize amide-linked antisense oligonucleotides, a general chemical approach was developed for the synthesis of building blocks in which an amino group and a carboxylic group are contained at the 5' and 3' positions of a nucleoside. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：193 / 197

页数：5

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