Synthesis of 1-(5-amino-3,5-dideoxy-3-methoxycarbonylmethyl-β-D-ribofuranosyl)thymine

被引:7
|
作者
Lu, DM [1 ]
Min, JM [1 ]
Zhang, LH [1 ]
机构
[1] Beijing Med Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
基金
中国国家自然科学基金;
关键词
thymidine analogue; oligonucleotides; stereoselective synthesis;
D O I
10.1016/S0008-6215(99)00057-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In order to synthesize amide-linked antisense oligonucleotides, a general chemical approach was developed for the synthesis of building blocks in which an amino group and a carboxylic group are contained at the 5' and 3' positions of a nucleoside. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:193 / 197
页数:5
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