Biomimetic synthesis of (-)-longithorone A

被引：177

作者：

Layton, ME ^{[1
]}

Morales, CA ^{[1
]}

Shair, MD ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 05期

关键词：

D O I：

10.1021/ja016585u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An enantioseletive, biomimetic synthesis of (-)-longithorone A has been achieved using an intermolecular/transannular Diels-Alder sequence which provides some support for the proposed biosynthesis. The cycloaddition precursors were two [12]-paracyclophanes that were constructed with atropisomer control during ene-yne metathesis macrocyclizations. Copyright © 2002 American Chemical Society.

引用

页码：773 / 775

页数：3

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