共 31 条
A Single Amino Acid Substitution in the Group 1 Trypanosoma brucei gambiense Haptoglobin-Hemoglobin Receptor Abolishes TLF-1 Binding
被引:39
作者:

DeJesus, E.
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Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA

Kieft, R.
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Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA

Albright, B.
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Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA

Stephens, N. A.
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Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA

Hajduk, S. L.
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Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA
机构:
[1] Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA
关键词:
RESISTANCE-ASSOCIATED PROTEIN;
LYTIC FACTOR;
INNATE IMMUNITY;
HUMAN-SERUM;
MECHANISM;
COMPLEX;
ROLES;
LYSIS;
GENE;
D O I:
10.1371/journal.ppat.1003317
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Critical to human innate immunity against African trypanosomes is a minor subclass of human high-density lipoproteins, termed Trypanosome Lytic Factor-1 (TLF-1). This primate-specific molecule binds to a haptoglobin-hemoglobin receptor (HpHbR) on the surface of susceptible trypanosomes, initiating a lytic pathway. Group 1 Trypanosoma brucei gambiense causes human African Trypanosomiasis (HAT), escaping TLF-1 killing due to reduced uptake. Previously, we found that group 1 T. b. gambiense HpHbR (TbgHpHbR) mRNA levels were greatly reduced and the gene contained substitutions within the open reading frame. Here we show that a single, highly conserved amino acid in the TbgHpHbR ablates high affinity TLF-1 binding and subsequent endocytosis, thus evading TLF-1 killing. In addition, we show that over-expression of TbgHpHbR failed to rescue TLF-1 susceptibility. These findings suggest that the single substitution present in the TbgHpHbR directly contributes to the reduced uptake and resistance to TLF-1 seen in these important human pathogens.
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共 31 条
[1]
Insight into the mechanism of trypanosome lytic factor-1 killing of Trypanosoma brucei brucei
[J].
Bishop, JR
;
Shimamura, M
;
Hajduk, SL
.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY,
2001, 118 (01)
:33-40

Bishop, JR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Alabama, Sch Med, Dept Biochem & Mol Genet, Birmingham, AL 35294 USA

Shimamura, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Alabama, Sch Med, Dept Biochem & Mol Genet, Birmingham, AL 35294 USA

Hajduk, SL
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama, Sch Med, Dept Biochem & Mol Genet, Birmingham, AL 35294 USA Univ Alabama, Sch Med, Dept Biochem & Mol Genet, Birmingham, AL 35294 USA
[2]
Haptoglobin-hemoglobin receptor independent killing of African trypanosomes by human serum and trypanosome lytic factors
[J].
Bullard, Whitney
;
Kieft, Rudo
;
Capewell, Paul
;
Veitch, Nicola J.
;
Macleod, Annette
;
Hajduk, Stephen L.
.
VIRULENCE,
2012, 3 (01)
:72-76

Bullard, Whitney
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA Wellcome Ctr Mol Parasitol, Fac Vet Med, Glasgow, Lanark, Scotland

Kieft, Rudo
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA Wellcome Ctr Mol Parasitol, Fac Vet Med, Glasgow, Lanark, Scotland

Capewell, Paul
论文数: 0 引用数: 0
h-index: 0
机构:
Wellcome Ctr Mol Parasitol, Fac Vet Med, Glasgow, Lanark, Scotland Wellcome Ctr Mol Parasitol, Fac Vet Med, Glasgow, Lanark, Scotland

Veitch, Nicola J.
论文数: 0 引用数: 0
h-index: 0
机构:
Wellcome Ctr Mol Parasitol, Fac Vet Med, Glasgow, Lanark, Scotland Wellcome Ctr Mol Parasitol, Fac Vet Med, Glasgow, Lanark, Scotland

Macleod, Annette
论文数: 0 引用数: 0
h-index: 0
机构:
Wellcome Ctr Mol Parasitol, Fac Vet Med, Glasgow, Lanark, Scotland Wellcome Ctr Mol Parasitol, Fac Vet Med, Glasgow, Lanark, Scotland

Hajduk, Stephen L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA Wellcome Ctr Mol Parasitol, Fac Vet Med, Glasgow, Lanark, Scotland
[3]
The origin of the serum resistance associated (SRA) gene and a model of the structure of the SRA polypeptide from Trypanosoma brucei rhodesiense
[J].
Campillo, N
;
Carrington, M
.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY,
2003, 127 (01)
:79-84

Campillo, N
论文数: 0 引用数: 0
h-index: 0
机构:
Dept Biochem, Cambridge CB2 1GA, England Dept Biochem, Cambridge CB2 1GA, England

Carrington, M
论文数: 0 引用数: 0
h-index: 0
机构:
Dept Biochem, Cambridge CB2 1GA, England Dept Biochem, Cambridge CB2 1GA, England
[4]
Differences between Trypanosoma brucei gambiense Groups 1 and 2 in Their Resistance to Killing by Trypanolytic Factor 1
[J].
Capewell, Paul
;
Veitch, Nicola J.
;
Turner, C. Michael R.
;
Raper, Jayne
;
Berriman, Matthew
;
Hajduk, Stephen L.
;
MacLeod, Annette
.
PLOS NEGLECTED TROPICAL DISEASES,
2011, 5 (09)

Capewell, Paul
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Glasgow, Coll Med Vet & Biol Sci, Wellcome Trust Ctr Mol Parasitol, Glasgow, Lanark, Scotland Univ Glasgow, Coll Med Vet & Biol Sci, Wellcome Trust Ctr Mol Parasitol, Glasgow, Lanark, Scotland

Veitch, Nicola J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Glasgow, Coll Med Vet & Biol Sci, Wellcome Trust Ctr Mol Parasitol, Glasgow, Lanark, Scotland Univ Glasgow, Coll Med Vet & Biol Sci, Wellcome Trust Ctr Mol Parasitol, Glasgow, Lanark, Scotland

Turner, C. Michael R.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Glasgow, Coll Med Vet & Biol Sci, Wellcome Trust Ctr Mol Parasitol, Glasgow, Lanark, Scotland

Raper, Jayne
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Dept Microbiol, Langone Sch Med, New York, NY 10016 USA Univ Glasgow, Coll Med Vet & Biol Sci, Wellcome Trust Ctr Mol Parasitol, Glasgow, Lanark, Scotland

Berriman, Matthew
论文数: 0 引用数: 0
h-index: 0
机构:
Wellcome Trust Sanger Inst, Hinxton, England Univ Glasgow, Coll Med Vet & Biol Sci, Wellcome Trust Ctr Mol Parasitol, Glasgow, Lanark, Scotland

Hajduk, Stephen L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA Univ Glasgow, Coll Med Vet & Biol Sci, Wellcome Trust Ctr Mol Parasitol, Glasgow, Lanark, Scotland

MacLeod, Annette
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Glasgow, Coll Med Vet & Biol Sci, Wellcome Trust Ctr Mol Parasitol, Glasgow, Lanark, Scotland Univ Glasgow, Coll Med Vet & Biol Sci, Wellcome Trust Ctr Mol Parasitol, Glasgow, Lanark, Scotland
[5]
Heme Uptake by Leishmania amazonensis Is Mediated by the Transmembrane Protein LHR1
[J].
Chau Huynh
;
Yuan, Xiaojing
;
Miguel, Danilo C.
;
Renberg, Rebecca L.
;
Protchenko, Olga
;
Philpott, Caroline C.
;
Hamza, Iqbal
;
Andrews, Norma W.
.
PLOS PATHOGENS,
2012, 8 (07)
:36

Chau Huynh
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA

Yuan, Xiaojing
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA
Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA

Miguel, Danilo C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA

Renberg, Rebecca L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA

Protchenko, Olga
论文数: 0 引用数: 0
h-index: 0
机构:
NIDDK, Genet & Metab Sect, Liver Dis Branch, NIH, Bethesda, MD USA Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA

Philpott, Caroline C.
论文数: 0 引用数: 0
h-index: 0
机构:
NIDDK, Genet & Metab Sect, Liver Dis Branch, NIH, Bethesda, MD USA Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA

Hamza, Iqbal
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA
Univ Maryland, Dept Anim & Avian Sci, College Pk, MD 20742 USA Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA

Andrews, Norma W.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA Univ Maryland, Dept Cell Biol & Mol Genet, College Pk, MD 20742 USA
[6]
A GENE EXPRESSED ONLY IN SERUM-RESISTANT VARIANTS OF TRYPANOSOMA-BRUCEI-RHODESIENSE
[J].
DEGREEF, C
;
IMBERECHTS, H
;
MATTHYSSENS, G
;
VANMEIRVENNE, N
;
HAMERS, R
.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY,
1989, 36 (02)
:169-176

DEGREEF, C
论文数: 0 引用数: 0
h-index: 0
机构: PLANT GENET SYST NV,GHENT,BELGIUM

IMBERECHTS, H
论文数: 0 引用数: 0
h-index: 0
机构: PLANT GENET SYST NV,GHENT,BELGIUM

MATTHYSSENS, G
论文数: 0 引用数: 0
h-index: 0
机构: PLANT GENET SYST NV,GHENT,BELGIUM

VANMEIRVENNE, N
论文数: 0 引用数: 0
h-index: 0
机构: PLANT GENET SYST NV,GHENT,BELGIUM

HAMERS, R
论文数: 0 引用数: 0
h-index: 0
机构: PLANT GENET SYST NV,GHENT,BELGIUM
[7]
Haptoglobin-related protein mediates trypanosome lytic factor binding to trypanosomes
[J].
Drain, J
;
Bishop, JR
;
Hajduk, SL
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2001, 276 (32)
:30254-30260

Drain, J
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama, Sch Med, Dept Biochem & Mol Genet, Birmingham, AL 35294 USA Univ Alabama, Sch Med, Dept Biochem & Mol Genet, Birmingham, AL 35294 USA

Bishop, JR
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama, Sch Med, Dept Biochem & Mol Genet, Birmingham, AL 35294 USA Univ Alabama, Sch Med, Dept Biochem & Mol Genet, Birmingham, AL 35294 USA

Hajduk, SL
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Alabama, Sch Med, Dept Biochem & Mol Genet, Birmingham, AL 35294 USA Univ Alabama, Sch Med, Dept Biochem & Mol Genet, Birmingham, AL 35294 USA
[8]
In vitro generation of human high-density-lipoprotein-resistant Trypanosoma brucei brucei
[J].
Faulkner, Sara D.
;
Oli, Monika W.
;
Kieft, Rudo
;
Cotlin, Laura
;
Widener, Justin
;
Shiflett, April
;
Cipriano, Michael J.
;
Pacocha, Sarah E.
;
Birkeland, Shanda R.
;
Hajduk, Stephen L.
;
McArthur, Andrew G.
.
EUKARYOTIC CELL,
2006, 5 (08)
:1276-1286

Faulkner, Sara D.
论文数: 0 引用数: 0
h-index: 0
机构: Josephine Bay Paul Ctr, Marine Biol Lab, Global Infect Dis Program, Woods Hole, MA 02543 USA

Oli, Monika W.
论文数: 0 引用数: 0
h-index: 0
机构: Josephine Bay Paul Ctr, Marine Biol Lab, Global Infect Dis Program, Woods Hole, MA 02543 USA

Kieft, Rudo
论文数: 0 引用数: 0
h-index: 0
机构: Josephine Bay Paul Ctr, Marine Biol Lab, Global Infect Dis Program, Woods Hole, MA 02543 USA

Cotlin, Laura
论文数: 0 引用数: 0
h-index: 0
机构: Josephine Bay Paul Ctr, Marine Biol Lab, Global Infect Dis Program, Woods Hole, MA 02543 USA

Widener, Justin
论文数: 0 引用数: 0
h-index: 0
机构: Josephine Bay Paul Ctr, Marine Biol Lab, Global Infect Dis Program, Woods Hole, MA 02543 USA

Shiflett, April
论文数: 0 引用数: 0
h-index: 0
机构: Josephine Bay Paul Ctr, Marine Biol Lab, Global Infect Dis Program, Woods Hole, MA 02543 USA

Cipriano, Michael J.
论文数: 0 引用数: 0
h-index: 0
机构: Josephine Bay Paul Ctr, Marine Biol Lab, Global Infect Dis Program, Woods Hole, MA 02543 USA

Pacocha, Sarah E.
论文数: 0 引用数: 0
h-index: 0
机构: Josephine Bay Paul Ctr, Marine Biol Lab, Global Infect Dis Program, Woods Hole, MA 02543 USA

Birkeland, Shanda R.
论文数: 0 引用数: 0
h-index: 0
机构: Josephine Bay Paul Ctr, Marine Biol Lab, Global Infect Dis Program, Woods Hole, MA 02543 USA

Hajduk, Stephen L.
论文数: 0 引用数: 0
h-index: 0
机构: Josephine Bay Paul Ctr, Marine Biol Lab, Global Infect Dis Program, Woods Hole, MA 02543 USA

McArthur, Andrew G.
论文数: 0 引用数: 0
h-index: 0
机构: Josephine Bay Paul Ctr, Marine Biol Lab, Global Infect Dis Program, Woods Hole, MA 02543 USA
[9]
Evidence for a Trypanosoma brucei lipoprotein scavenger receptor
[J].
Green, HP
;
Portela, MDM
;
St Jean, EN
;
Lugli, EB
;
Raper, J
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2003, 278 (01)
:422-427

Green, HP
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Sch Med, Dept Med & Mol Parasitol, New York, NY 10010 USA NYU, Sch Med, Dept Med & Mol Parasitol, New York, NY 10010 USA

Portela, MDM
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Sch Med, Dept Med & Mol Parasitol, New York, NY 10010 USA NYU, Sch Med, Dept Med & Mol Parasitol, New York, NY 10010 USA

St Jean, EN
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Sch Med, Dept Med & Mol Parasitol, New York, NY 10010 USA NYU, Sch Med, Dept Med & Mol Parasitol, New York, NY 10010 USA

Lugli, EB
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Sch Med, Dept Med & Mol Parasitol, New York, NY 10010 USA NYU, Sch Med, Dept Med & Mol Parasitol, New York, NY 10010 USA

Raper, J
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Sch Med, Dept Med & Mol Parasitol, New York, NY 10010 USA NYU, Sch Med, Dept Med & Mol Parasitol, New York, NY 10010 USA
[10]
ENDOCYTOSIS OF A CYTOTOXIC HUMAN HIGH-DENSITY-LIPOPROTEIN RESULTS IN DISRUPTION OF ACIDIC INTRACELLULAR VESICLES AND SUBSEQUENT KILLING OF AFRICAN TRYPANOSOMES
[J].
HAGER, KM
;
PIERCE, MA
;
MOORE, DR
;
TYTLER, EM
;
ESKO, JD
;
HAJDUK, SL
.
JOURNAL OF CELL BIOLOGY,
1994, 126 (01)
:155-167

HAGER, KM
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT BIOCHEM & MOLEC GENET,BIRMINGHAM,AL 35294

PIERCE, MA
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT BIOCHEM & MOLEC GENET,BIRMINGHAM,AL 35294

MOORE, DR
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT BIOCHEM & MOLEC GENET,BIRMINGHAM,AL 35294

TYTLER, EM
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT BIOCHEM & MOLEC GENET,BIRMINGHAM,AL 35294

ESKO, JD
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT BIOCHEM & MOLEC GENET,BIRMINGHAM,AL 35294

HAJDUK, SL
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ALABAMA,DEPT BIOCHEM & MOLEC GENET,BIRMINGHAM,AL 35294