Sustained response of malignant pericardial effusion to intrapericardial bevacizumab in an advanced lung cancer patient: a case report and literature review

被引：8
|
作者：
Chen, Dawei [1 ,2 ]
Zhang, Yan [2 ]
Shi, Fang [2 ]
Li, Minghuan [2 ]
Zhu, Hui [2 ]
Kong, Li [2 ]
Yu, Jinming [2 ]
机构：
[1] Weifang Med Univ, Weifang, Peoples R China
[2] Shandong Canc Hosp & Inst, Dept Radiat Oncol, Jinan 250117, Shandong, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2015年 / 8卷
关键词：
bevacizumab; lung cancer; malignant pericardial effusion; ENDOTHELIAL GROWTH-FACTOR; PLEURAL EFFUSIONS; CISPLATIN; ASCITES;
D O I：
10.2147/OTT.S90145
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Malignant pericardial effusion (MPCE) is a common complication of advanced malignant tumors, and interferes severely with patient prognosis and quality of life. The standard treatment for this complication is intracavitary perfusion of chemotherapeutic drugs, which is limited by unsatisfactory therapeutic effects and serious adverse events. We report a patient with MPCE who was treated with bevacizumab by pericardial perfusion, resulting in a complete response. This case supports the use of intrapericardial bevacizumab as a potential treatment for MPCE.
引用
收藏
页码：2767 / 2770
页数：4
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