Depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities

被引：18

作者：

Cho, Jun-Cheol ^{[2
]}

Rho, Ho Sik ^{[1
]}

Joo, Yung Hyup ^{[1
]}

Lee, Chang Seok ^{[1
]}

Lee, Jaekyoung ^{[1
]}

Ahn, Soo Mi ^{[3
]}

Kim, Jung Eun ^{[4
]}

Shin, Song Seok ^{[1
]}

Park, Young-Ho ^{[1
]}

Suh, Kyung-Do ^{[2
]}

Park, Soo Nam ^{[4
]}

机构：

[1] AmorePacific Corp, R&D Ctr, Yongin 446729, South Korea

[2] Hanyang Univ, Coll Engn, Div Chem Engn, Seoul 133791, South Korea

[3] Kyung Hee Univ, Skin Biotechnol Ctr, Suwon 443270, South Korea

[4] Seoul Natl Univ Sci & Technol, Dept Fine Chem, Seoul 139743, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 12期

关键词：

Depigmentation; Tyrosinase; Hydroxylbenzoic acid; Kojic acid; KOJYL THIOETHER DERIVATIVES;

D O I：

10.1016/j.bmcl.2012.04.046

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We synthesized benzoate ester derivatives of kojic acid with and without adamantane moiety. Benzoate derivatives 2a-e that did not contain an adamantane moiety showed potent tyrosinase inhibitory activities. However, depigmenting activity was not noted in a cell-based assay. Contrasting results were obtained for benzoate derivatives (3a-e) containing an adamantane moiety. Compounds 3a-e showed potent depigmenting activities without tyrosinase inhibitory activities. To the best of our knowledge, this is the first study showing the depigmenting activities of kojic acid derivatives without tyrosinase inhibitory activities. (C) 2012 Published by Elsevier Ltd.

引用

页码：4159 / 4162

页数：4

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