Synthesis of Chiral Aliphatic Amines through Asymmetric Hydrogenation

被引：59

作者：

Liu, Tang-Lin ^{[1
]}

Wang, Chun-Jiang ^{[1
]}

Zhang, Xumu ^{[1
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 32期

关键词：

amines; asymmetric catalysis; hydrogenation; rhodium; KETONES; 1,2-ADDITION; CATALYSTS; REAGENTS; ACCESS; ETHERS; POTENT;

D O I：

10.1002/anie.201302943

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The direct route: A Rhodium-catalyzed asymmetric hydrogenation method for the efficient synthesis of a broad range of chiral allylic amines and aliphatic amines from readily available materials was developed. A chiral Z-allylic amine was obtained for the first time through a Rhodium-DuanPhos-catalyzed asymmetric hydrogenation. TMS=Trimethylsilyl, cod=cyclooctadiene, TON=turnover number. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：8416 / 8419

页数：4

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