RMPs: Recombination/replication mediator proteins

被引：108

作者：

Beernink, HTH ^{[1
]}

Morrical, SW

机构：

[1] Univ Vermont, Coll Med, Dept Biochem, Burlington, VT 05405 USA

[2] Univ Vermont, Coll Med, Ctr Xray Crystallog, Burlington, VT 05405 USA

[3] Univ Vermont, Coll Med, Dept Microbiol & Mol Genet, Burlington, VT 05405 USA

[4] Univ Vermont, Coll Med, Vermont Canc Ctr, Burlington, VT 05405 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1999年 / 24卷 / 10期

关键词：

D O I：

10.1016/S0968-0004(99)01451-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Enzymes for DNA replication and recombination need to gain access to single-stranded DNA (ssDNA) but ssDNA-binding proteins (SSBs) present an obstacle to the formation of enzyme-ssDNA replication and recombination complexes. A specialized class of SSBs, which we designate as recombination/replication mediator proteins (RMPs), promotes enzyme-ssDNA assembly by overcoming SSB inhibition. RMPs exhibit strong conservation of function across divergent species, and display species-specific interactions with SSB and enzymes to neutralize the SSB barrier to enzyme-ssDNA assembly.

引用

页码：385 / 389

页数：5

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