FREE FLAP FAILURE SECONDARY TO DUAL THROMBOPHILIA

被引:16
作者
Davis, Michael Robert [1 ]
Shell, Daniel Huff [1 ]
Marques, Marisa [2 ]
Long, James Neal [1 ]
机构
[1] Univ Alabama Birmingham, Sch Med, Div Plast Surg, Birmingham, AL 35294 USA
[2] Univ Alabama Birmingham, Sch Med, Dept Pathol, Birmingham, AL 35294 USA
关键词
DEEP-VEIN THROMBOSIS; RISK-FACTOR; VASCULAR-DISEASE; PLASMA-LEVELS; FACTOR-VIII; VENOUS THROMBOEMBOLISM; PROTHROMBIN GENE; PROTEIN-C; HOMOCYSTEINE; DEFICIENCY;
D O I
10.1002/micr.20553
中图分类号
R61 [外科手术学];
学科分类号
摘要
Much has been learned over the past several decades regarding thrombophilic conditions. Thrombotic complications, such as deep venous thrombosis, pulmonary embolus, myocardial infarction, and stroke, are sometimes attributed to a diagnosable thrombophilia. Less has been written with regard to their effect on reconstructive outcomes. Fortunately, it is rare to encounter a notable intraoperative thrombophilia while performing reconstructive microsurgery. When this does occur, salvage can be difficult and outcome can be compromised. It is imperative that microsurgeons be knowledgeable of both major and minor thrombogenic conditions to optimize intraoperative outcome and postoperative care. We present a case of a failed free flap for lower extremity reconstruction associated with hyperhomocysteinemia in conjunction with markedly elevated Factor VIII levels. (C) 2008 Wiley-Liss, Inc. Microsurgery 29:62-65, 2009.
引用
收藏
页码:62 / 65
页数:4
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