Induced pluripotent stem cells and hepatic differentiation

被引：10

作者：

Chiang, Chih-Hung ^{[1
,2
,3
]}

Huo, Teh-Ia ^{[1
,4
]}

Sun, Cho-Chin ^{[2
,3
]}

Hsieh, Jung-Hung ^{[2
,3
]}

Chien, Yueh ^{[6
]}

Lu, Kai-Hsi ^{[5
,6
,7
]}

Lee, Shou-Dong ^{[6
,8
]}

机构：

[1] Natl Yang Ming Univ, Inst Pharmacol, Taipei 112, Taiwan

[2] Taipei Vet Gen Hosp, Dept Surg, Div Urol, Yi Lan, Taiwan

[3] Su Ao Yuan Shan Branch, Yi Lan, Taiwan

[4] Taipei Vet Gen Hosp, Dept Internal Med, Div Gastroenterol, Taipei, Taiwan

[5] Cheng Hsin Gen Hosp, Dept Med Res & Educ, Taipei 112, Taiwan

[6] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

[7] Fu Jen Catholic Univ, Grad Inst Basic Med, New Taipei City, Taiwan

[8] Cheng Hsin Gen Hosp, Dept Med, Div Gastroenterol, Taipei, Taiwan

来源：

JOURNAL OF THE CHINESE MEDICAL ASSOCIATION | 2013年 / 76卷 / 11期

关键词：

hepatic repair; induced pluripotent stem cells; DIRECTED DIFFERENTIATION; HUMAN ES; C-MYC; PARKINSONS-DISEASE; SOMATIC-CELLS; IPS CELLS; GENERATION; TRANSPLANTATION; INDUCTION; HEPATOCYTES;

D O I：

10.1016/j.jcma.2013.07.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Induced pluripotent stem cells (iPSCs) are generated by reprogramming somatic cells to a pluripotent state by the introduction of specific factors. They can be generated from cells of different origins, such as fibroblasts, keratinocytes, hepatocytes, and blood. iPSCs are similar to embryonic stem cells (ESCs) in several aspects, such as morphology, expression of pluripotency markers, and the ability to develop teratoma that contains tissue from three germ layers. In addition, iPSCs can undergo tridermal differentiation, including hepatic specific lineages. Considering that iPSCs could be a source of hepatocyte regeneration, iPSC-based therapy has been widely implicated in the treatment of liver disease and hepatic regeneration. In the present review, we discuss the therapeutic potential of iPSCs in hepatic repair and focus on the clinical applications of iPSCs. Copyright (C) 2013 Elsevier Taiwan LLC and the Chinese Medical Association. All rights reserved.

引用

页码：599 / 605

页数：7

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