Microencapsulated cell tracking

被引：28

作者：

Arifin, Dian R. ^{[1
,5
,6
]}

Kedziorek, Dorota A. ^{[1
]}

Fu, Yingli ^{[1
]}

Chan, Kannie W. Y. ^{[1
,5
,6
]}

McMahon, Michael T. ^{[1
,7
]}

Weiss, Clifford R. ^{[1
]}

Kraitchman, Dara L. ^{[1
,8
]}

Bulte, Jeff W. M. ^{[1
,2
,3
,4
,5
,6
,7
]}

机构：

[1] Johns Hopkins Univ, Russell H Morgan Dept Radiol & Radiol Sci, Sch Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Dept Biomed Engn, Sch Med, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Dept Chem & Biomol Engn, Sch Med, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Dept Oncol, Sch Med, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Inst Cell Engn, Sch Med, Cellular Imaging Sect, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Inst Cell Engn, Sch Med, Vasc Biol Program, Baltimore, MD 21205 USA

[7] Johns Hopkins Univ, FM Kirby Res Ctr Funct Brain Imaging, Sch Med, Kennedy Krieger Inst, Baltimore, MD 21205 USA

[8] Johns Hopkins Univ, Dept Mol & Comparat Pathobiol, Sch Med, Baltimore, MD 21205 USA

来源：

NMR IN BIOMEDICINE | 2013年 / 26卷 / 07期

基金：

美国国家卫生研究院;

关键词：

microcapsules; cell therapy; diabetes; islet cell transplantation; MRI; ultrasound imaging; computed tomography; contrast agent; ALGINATE-POLYLYSINE MICROCAPSULES; TYPE-1; DIABETIC-PATIENT; MAGNETIC-RESONANCE; STEM-CELLS; X-RAY; CAPSULE COMPOSITION; OXYGEN-TENSION; PORCINE ISLETS; HOST-REACTION; IMMUNOPROTECTION;

D O I：

10.1002/nbm.2894

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Microencapsulation of therapeutic cells has been widely pursued to achieve cellular immunoprotection following transplantation. Initial clinical studies have shown the potential of microencapsulation using semi-permeable alginate layers, but much needs to be learned about the optimal delivery route, in vivo pattern of engraftment, and microcapsule stability over time. In parallel with noninvasive imaging techniques for naked' (i.e. unencapsulated) cell tracking, microcapsules have now been endowed with contrast agents that can be visualized by 1H MRI, 19F MRI, X-ray/computed tomography and ultrasound imaging. By placing the contrast agent formulation in the extracellular space of the hydrogel, large amounts of contrast agents can be incorporated with negligible toxicity. This has led to a new generation of imaging biomaterials that can render cells visible with multiple imaging modalities. Copyright (c) 2012 John Wiley & Sons, Ltd.

引用

页码：850 / 859

页数：10

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