Nickel-Catalyzed Cross-Coupling of Umpolung Carbonyls and Alkyl Halides

被引：19

作者：

Zhu, Dianhu

Lv, Leiyang

Qu, Zihang

Li, Chao-Jun ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, 801 Sherbrooke St W, Montreal, PQ H3A 0B8, Canada

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 10期

基金：

加拿大自然科学与工程研究理事会;

关键词：

ARYL GRIGNARD-REAGENTS; BROMIDES; EFFICIENT; BENZYLATION; ALDEHYDES; CHLORIDES; IODIDES; 1,3-BUTADIENE; TOSYLATES; BONDS;

D O I：

10.1021/acs.joc.9b00649

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An effective nickel-catalyzed cross-coupling of Umpolung carbonyls and alkyl halides was developed. Complementary to classical alkylation techniques, this reaction utilizes Umpolung carbonyls as the environmentally benign alkyl nucleophiles, providing an efficient and selective catalytic alternative to the traditional use of highly reactive alkyl organo-metallic reagents.

引用

收藏

页码：6312 / 6322

页数：11

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